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Guidelines

MIRAGE

phosphoinositide kinase, FYVE-type zinc finger containing

Summary

Gene Symbol

PIKFYVE

Organism

Rhinolophus ferrumequinum (greater horseshoe bat)

External Links

NCBI Gene: 117025879
KEGG Gene ID: rfq:117025879
PubChem: 117025879

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
intracellular signal transduction	IEA	22301074
phosphatidylinositol metabolic process	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

Displaying **all 3** entries
GO Term	Evidence Code	PMID
1-phosphatidylinositol-3-phosphate 5-kinase activity	IEA	22301074 30032202
ATP binding	IEA	22301074
metal ion binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

phosphatidylinositol kinase activity [inference]

1-phosphatidylinositol-3-phosphate 5-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphatidylinositol kinase activity [inference]

1-phosphatidylinositol-3-phosphate 5-kinase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatidylinositol 3-phosphate 5-kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
1-phosphatidylinositol-3-phosphate 5-kinase activity
ATP binding
kinase activity
metal ion binding
nucleotide binding
phosphatidylinositol kinase activity
phosphorylation
transferase activity

Displaying **all 10** entries
InterPro
1-phosphatidylinositol-3-phosphate 5-kinase, PIPK catalytic domain
Chaperonin Cpn60/GroEL/TCP-1 family
FYVE zinc finger
GroEL-like apical domain superfamily
Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
Phosphatidylinositol-4-phosphate 4/5-kinase, core
Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
Zinc finger, FYVE-related
Zinc finger, FYVE/PHD-type
Zinc finger, RING/FYVE/PHD-type

KEGG BRITE Database

Orthology

K00921

Name

1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]

References

Ortholog

Displaying entries **21 - 30** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cricetulus griseus	100758487		CRIGR16034
Sarcophilus harrisii	100933218		SARHA09041
Otolemur garnettii	100961500		OTOGA16098
Pan paniscus	100981447		PANPA26558
Papio anubis	101019788		PAPAN02247
Saimiri boliviensis boliviensis	101028683		SAIBB09528
Takifugu rubripes	101078741		TAKRU24213
Felis catus	101094121		FELCA19420
Ovis aries	101120727		SHEEP09706
Gorilla gorilla gorilla	101152226		GORGO27014

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Last updated: August 4, 2025