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hephaestin

Summary

Gene Symbol

Heph

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

117240

PubChem

117240

Alliance of Genome Resources

RGD:71060

Annotation

Keyword

Calcium
Cell membrane
Disulfide bond
Glycoprotein
Iron transport
Metal-binding
Oxidoreductase
Phosphoprotein
Reference proteome
Repeat
Signal
Sodium
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q920H8
A6IQ46

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
iron ion transport
multicellular organismal-level iron ion homeostasis	ISS
multicellular organismal-level iron ion homeostasis	ISO
multicellular organismal-level iron ion homeostasis	IEA
intestinal iron absorption	ISS

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal iron absorption

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

multicellular organismal-level iron ion homeostasis

inorganic ion homeostasis [inference]

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of iron ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
basolateral plasma membrane	ISS
basolateral plasma membrane	ISO
basolateral plasma membrane	IEA
perinuclear region of cytoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
ferroxidase activity	ISS
ferroxidase activity	ISO
ferroxidase activity	IBA
ferroxidase activity	IEA
copper ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on metal ions [inference]

oxidoreductase activity, acting on metal ions, oxygen as acceptor [inference]

ferroxidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hephaestin-like protein

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
copper ion binding
metal ion binding
oxidoreductase activity

Displaying **all 5** entries
InterPro
Cupredoxin
Multicopper oxidase, C-terminal
Multicopper oxidase, copper-binding site
Multicopper oxidase-like, N-terminal
Multicopper oxidases, conserved site