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ATPase, class V, type 10A

Summary

Gene Symbol

Atp10a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

11982

PubChem

11982

Alliance of Genome Resources

MGI:1330809

Annotation

Keyword

ATP-binding
Cell membrane
Endoplasmic reticulum
Lipid transport
Magnesium
Metal-binding
Phosphoprotein
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
O54827	ATPase class V type 10A P-locus fat-associated ATPase P4-ATPase flippase complex alpha subunit ATP10A
Q6A046
Q3V1Y7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phospholipid transport	IEA
lipid translocation	IEA
phospholipid translocation	IBA
positive regulation of membrane tubulation	ISS
positive regulation of membrane tubulation	ISO

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

phospholipid translocation

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport [inference]

phospholipid transport

phospholipid translocation

lipid translocation

phospholipid translocation

organophosphate ester transport [inference]

phospholipid transport

phospholipid translocation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of membrane tubulation

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of membrane tubulation

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of membrane tubulation

regulation of plasma membrane organization [inference]

regulation of membrane tubulation [inference]

positive regulation of membrane tubulation

regulation of biological quality [inference]

regulation of membrane lipid distribution [inference]

lipid translocation

phospholipid translocation

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISO
endoplasmic reticulum membrane	IEA
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

transporter complex [inference]

phospholipid-translocating ATPase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

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GO Term	Evidence Code	PMID
magnesium ion binding	IEA
ATP binding	IEA
ATP hydrolysis activity	IEA
phosphatidylcholine floppase activity	IEA
ATPase-coupled intramembrane lipid transporter activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phosphatidylcholine transporter activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

sphingolipid transporter activity [inference]

glycosylceramide flippase activity

intramembrane lipid transporter activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

glycosylceramide flippase activity

floppase activity [inference]

phosphatidylcholine floppase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled intramembrane lipid transporter activity

flippase activity [inference]

glycerophospholipid flippase activity [inference]

phosphatidylcholine flippase activity

glycosylceramide flippase activity

floppase activity [inference]

phosphatidylcholine floppase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

HAD ATPase

Functional Category

C: Energy production and conversion
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
lipid translocation
magnesium ion binding
metal ion binding
nucleotide binding
phospholipid translocation
phospholipid transport

Displaying entries **1 - 10** of 11 in total

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InterPro
HAD superfamily
HAD-like superfamily
P-type ATPase, A domain superfamily
P-type ATPase, C-terminal
P-type ATPase, N-terminal
P-type ATPase, cytoplasmic domain N
P-type ATPase, haloacid dehalogenase domain
P-type ATPase, phosphorylation site
P-type ATPase, subfamily IV
P-type ATPase, transmembrane domain superfamily

Ortholog

Displaying entries **1 - 10** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	11982	Xenbase:XB-GENE-6033735
Saccharomyces cerevisiae S288C	23120	SGD:S000000968
Homo sapiens	57194		HUMAN21905
Saccharomyces cerevisiae S288C	291555	SGD:S000000968
Rattus norvegicus	365266		RATNO16129
Pan troglodytes	453268		PANTR09800
Canis lupus familiaris	488691		CANLF11973
Bos taurus	510723		BOVIN16285
Macaca mulatta	711435		MACMU41587
Equus caballus	100062211		HORSE16575