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Guidelines

MIRAGE

leucine rich repeat kinase 2

Summary

Gene Symbol

LRRK2

Aliases

DKFZp434H2111
FLJ45829
RIPK7
ROCO2
dardarin

Organism

Homo sapiens (human)

External Links

NCBI Gene

120892

HGNC

18618

PubChem

120892

Alliance of Genome Resources

HGNC:18618

JoGo

LRRK2

TogoVar

LRRK2

Annotation

Keyword

3D-structure
ATP-binding
Autophagy
Cell projection
Coiled coil
Cytoplasmic vesicle
Cytoskeleton
Differentiation
Disease variant
Endoplasmic reticulum
Endosome
GTP-binding
GTPase activation
Golgi apparatus
Hydrolase
Leucine-rich repeat
Lysosome
Mitochondrion outer membrane
Neurodegeneration
Parkinson disease
Parkinsonism
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Serine/threonine-protein kinase
Synapse
Ubl conjugation
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q17RV3
Q5S007	Dardarin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of **139** in total

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GO Term	Evidence Code	PMID
MAPK cascade	IDA
protein phosphorylation	IDA
protein phosphorylation	IMP
protein import into nucleus
endocytosis	IMP

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

intracellular signal transduction

intracellular signaling cassette [inference]

JNK cascade

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

calcium-mediated signaling

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

GTP metabolic process

phosphorylation [inference]

protein phosphorylation

protein autophosphorylation

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

GTP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

catabolic process [inference]

autophagy

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

GTP metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

protein autophosphorylation

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

GTP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

GTP metabolic process

intercellular transport [inference]

import into nucleus [inference]

protein import into nucleus

vesicle-mediated transport

endocytosis

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cell motility [inference]

cell migration [inference]

forebrain cell migration [inference]

telencephalon cell migration [inference]

tangential migration from the subventricular zone to the olfactory bulb

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to ether [inference]

cellular response to curcumin

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to ketone [inference]

cellular response to curcumin

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

Wnt signalosome assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

neuron projection arborization

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

Wnt signalosome assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

locomotory exploration behavior

exploration behavior

locomotory exploration behavior

determination of adult lifespan

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

anatomical structure morphogenesis

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

neuron projection arborization

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to starvation

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

response to starvation [inference]

cellular response to starvation

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to chemical [inference]

response to metal ion [inference]

response to manganese ion [inference]

cellular response to manganese ion

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to ether [inference]

cellular response to curcumin

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to ketone [inference]

cellular response to curcumin

response to nitrogen compound [inference]

response to monoamine [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to dopamine [inference]

cellular response to dopamine

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

response to ether [inference]

cellular response to ether [inference]

cellular response to curcumin

response to curcumin [inference]

cellular response to curcumin

response to catecholamine [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

response to dopamine [inference]

cellular response to dopamine

response to ketone [inference]

cellular response to ketone [inference]

cellular response to curcumin

response to curcumin [inference]

cellular response to curcumin

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to ether [inference]

cellular response to curcumin

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to ketone [inference]

cellular response to curcumin

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress

cellular response to reactive oxygen species

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to nitrogen compound [inference]

cellular response to monoamine stimulus [inference]

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to ether [inference]

cellular response to curcumin

cellular response to catecholamine stimulus [inference]

cellular response to dopamine

cellular response to ketone [inference]

cellular response to curcumin

localization [inference]

macromolecule localization [inference]

intracellular protein localization

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

protein localization to mitochondrion

protein localization to endoplasmic reticulum [inference]

protein localization to endoplasmic reticulum exit site

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

import into nucleus [inference]

protein import into nucleus

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

vesicle-mediated transport

endocytosis

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

import into cell [inference]

endocytosis

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

organelle localization [inference]

mitochondrion localization

mitochondrion distribution [inference]

intracellular distribution of mitochondria

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

regulation of dopamine receptor signaling pathway

positive regulation of dopamine receptor signaling pathway

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of intracellular signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of calcium-mediated signaling [inference]

regulation of CAMKK-AMPK signaling cascade

regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to mitochondrion [inference]

negative regulation of protein localization to mitochondrion

negative regulation of protein localization [inference]

negative regulation of protein localization to mitochondrion

regulation of transport [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

regulation of ER to Golgi vesicle-mediated transport

regulation of vacuolar transport [inference]

regulation of late endosome to lysosome transport [inference]

negative regulation of late endosome to lysosome transport

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

regulation of retrograde transport, endosome to Golgi

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle endocytosis

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of vesicle-mediated transport

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle endocytosis

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of synaptic vesicle transport

regulation of synaptic vesicle recycling [inference]

regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle endocytosis

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

regulation of ER to Golgi vesicle-mediated transport

regulation of vacuolar transport [inference]

regulation of late endosome to lysosome transport [inference]

negative regulation of late endosome to lysosome transport

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

regulation of retrograde transport, endosome to Golgi

regulation of locomotion

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of catabolic process [inference]

positive regulation of autophagy

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of programmed cell death

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of synaptic vesicle recycling [inference]

positive regulation of synaptic vesicle endocytosis

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of GTPase activity

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of autophagosome assembly

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of intracellular transport [inference]

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of autophagosome assembly

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

negative regulation of excitatory postsynaptic potential

negative regulation of protein localization [inference]

negative regulation of protein localization to mitochondrion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

regulation of dopamine receptor signaling pathway

positive regulation of dopamine receptor signaling pathway

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of intracellular signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of calcium-mediated signaling [inference]

regulation of CAMKK-AMPK signaling cascade

regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of inflammatory response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of neuroinflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of inflammatory response [inference]

positive regulation of inflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of neuroinflammatory response [inference]

positive regulation of neuroinflammatory response [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of a branching structure [inference]

regulation of branching morphogenesis of a nerve

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of neuron maturation

regulation of cell development [inference]

regulation of cell maturation [inference]

regulation of neuron maturation

regulation of cellular process [inference]

regulation of membrane depolarization [inference]

regulation of mitochondrial depolarization

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

intracellular signal transduction

intracellular signaling cassette [inference]

JNK cascade

small GTPase-mediated signal transduction [inference]

Rho protein signal transduction

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

regulation of dopamine receptor signaling pathway

positive regulation of dopamine receptor signaling pathway

regulation of Notch signaling pathway [inference]

negative regulation of Notch signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of intracellular signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of calcium-mediated signaling [inference]

regulation of CAMKK-AMPK signaling cascade

regulation of cAMP/PKA signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of synaptic transmission, glutamatergic

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of autophagosome assembly

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of catabolic process [inference]

positive regulation of autophagy

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of autophagosome assembly

positive regulation of catabolic process [inference]

positive regulation of autophagy

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of autophagy

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of autophagosome assembly

positive regulation of autophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy

negative regulation of autophagosome assembly

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein metabolic process [inference]

regulation of proteolysis

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

regulation of protein autoubiquitination [inference]

positive regulation of protein autoubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis

negative regulation of proteolysis [inference]

negative regulation of protein processing

regulation of protein processing [inference]

negative regulation of protein processing

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

regulation of post-translational protein modification [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

regulation of protein autoubiquitination [inference]

positive regulation of protein autoubiquitination

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

regulation of reactive oxygen species metabolic process

regulation of cell population proliferation [inference]

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of intrinsic apoptotic signaling pathway [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

positive regulation of programmed cell death

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of cilium assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of motile cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of organelle assembly [inference]

regulation of cilium assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of motile cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of organelle assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

negative regulation of autophagosome assembly

regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

regulation of neuron maturation

regulation of cell development [inference]

regulation of cell maturation [inference]

regulation of neuron maturation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of catabolic process [inference]

positive regulation of autophagy

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of protein metabolic process

positive regulation of protein modification process [inference]

positive regulation of post-translational protein modification [inference]

positive regulation of protein modification by small protein conjugation or removal [inference]

positive regulation of protein ubiquitination

positive regulation of protein autoubiquitination

positive regulation of protein catabolic process [inference]

positive regulation of proteasomal protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of ubiquitin-dependent protein catabolic process [inference]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of dopamine receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of programmed cell death

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of autophagosome assembly

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing

negative regulation of protein maturation [inference]

negative regulation of protein processing

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of Notch signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of intracellular transport [inference]

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of apoptotic signaling pathway [inference]

negative regulation of intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of autophagosome assembly

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle endocytosis

regulation of cell projection organization

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of cilium assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of motile cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of cilium assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of motile cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of autophagosome assembly

regulation of mitochondrion organization [inference]

regulation of mitochondrial fission

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of vacuole organization [inference]

regulation of autophagosome assembly [inference]

negative regulation of autophagosome assembly

regulation of organelle assembly [inference]

regulation of cilium assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

regulation of motile cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of organelle assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

negative regulation of autophagosome assembly

regulation of protein-containing complex assembly [inference]

regulation of SNARE complex assembly

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of organelle assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

negative regulation of autophagosome assembly

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of cilium assembly [inference]

negative regulation of motile cilium assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

regulation of ER to Golgi vesicle-mediated transport

regulation of vacuolar transport [inference]

regulation of late endosome to lysosome transport [inference]

negative regulation of late endosome to lysosome transport

negative regulation of vacuolar transport [inference]

negative regulation of late endosome to lysosome transport

regulation of retrograde transport, endosome to Golgi

regulation of vesicle-mediated transport

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of synaptic vesicle endocytosis

regulation of synaptic vesicle endocytosis

positive regulation of synaptic vesicle endocytosis

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

negative regulation of response to endoplasmic reticulum stress [inference]

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

regulation of synaptic vesicle transport

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of multicellular organismal process

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of system process [inference]

regulation of nervous system process [inference]

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of macrophage activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of microglial cell activation [inference]

positive regulation of microglial cell activation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of macrophage activation [inference]

positive regulation of microglial cell activation

regulation of morphogenesis of a branching structure [inference]

regulation of branching morphogenesis of a nerve

regulation of biological quality [inference]

regulation of protein stability

regulation of membrane potential

regulation of membrane depolarization [inference]

regulation of mitochondrial depolarization

regulation of mitochondrial membrane potential [inference]

regulation of mitochondrial depolarization

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

modulation of excitatory postsynaptic potential [inference]

negative regulation of excitatory postsynaptic potential

regulation of anatomical structure size [inference]

regulation of kidney size

regulation of membrane permeability [inference]

regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of membrane permeability [inference]

positive regulation of mitochondrial membrane permeability [inference]

positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

negative regulation of GTPase activity

negative regulation of hydrolase activity [inference]

negative regulation of GTPase activity

Displaying entries **1 - 5** of 84 in total

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GO Term	Evidence Code	PMID
Golgi membrane	EXP
Golgi membrane	IEA
extracellular region	HDA
obsolete extracellular space
nucleoplasm

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical structure [inference]

extracellular region

intracellular anatomical structure [inference]

inclusion body [inference]

Lewy body

nucleoplasm

neuron projection cytoplasm [inference]

dendrite cytoplasm

microtubule organizing center [inference]

ciliary basal body

presynaptic cytosol

membrane [inference]

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

organelle inner membrane [inference]

mitochondrial inner membrane

nuclear membrane

mitochondrial membrane

bounding membrane of organelle [inference]

Golgi membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

organelle outer membrane [inference]

mitochondrial outer membrane

plasma membrane region [inference]

caveola neck

membrane microdomain [inference]

cell junction [inference]

glutamatergic synapse

site of polarized growth [inference]

growth cone

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen

mitochondrial matrix

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

actin-based cell projection [inference]

microvillus

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

endosomal intralumenal vesicle [inference]

multivesicular body, internal vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

secondary lysosome [inference]

autolysosome

autophagosome [inference]

amphisome

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

endosomal intralumenal vesicle [inference]

multivesicular body, internal vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

secondary lysosome [inference]

autolysosome

autophagosome [inference]

amphisome

intracellular vesicle [inference]

cytoplasmic vesicle

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

endocytic vesicle [inference]

phagocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

endosomal intralumenal vesicle [inference]

multivesicular body, internal vesicle

intracellular membraneless organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

endoplasmic reticulum exit site

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of mitochondrial outer membrane

presynapse [inference]

terminal bouton

postsynapse

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GO Term	Evidence Code	PMID
SNARE binding	IPI
magnesium ion binding	IMP
actin binding	IPI
GTPase activity	EXP
GTPase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

protein kinase activity

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

JUN kinase kinase kinase activity

GTP-dependent protein kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

JUN kinase kinase kinase activity

GTP-dependent protein kinase activity

protein serine kinase activity

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

MAP kinase kinase kinase activity

JUN kinase kinase kinase activity

GTP-dependent protein kinase activity

protein serine kinase activity

binding [inference]

protein binding

syntaxin binding [inference]

syntaxin-1 binding

cytoskeletal protein binding [inference]

actin binding

tubulin binding

microtubule binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding

protein homodimerization activity

transmembrane transporter binding

protein dimerization activity [inference]

protein homodimerization activity

protein kinase A binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

protein-containing complex binding [inference]

beta-catenin destruction complex binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

signaling receptor complex adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peroxidase inhibitor activity

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peroxidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Leucine-rich repeat serine/threonine-protein kinase

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
GTP binding
kinase activity
nucleotide binding
phosphorylation

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InterPro
Ankyrin repeat-containing domain superfamily
C-terminal of Roc (COR) domain
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat
P-loop containing nucleoside triphosphate hydrolase
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Roc domain

Human Protein Atlas

ENSG00000188906

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

ATP

H⁺ + ADP

Enzyme

PMID

ATP

H⁺ + ADP

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060371	Parkinson's disease 8	Alliance of Genome Resources
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:162	cancer	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000338	Hypomimic face
HP:0000551	Color vision defect
HP:0000651	Diplopia
HP:0000713	Agitation
HP:0000716	Depression
HP:0000726	Dementia
HP:0000727	Frontal lobe dementia
HP:0000736	Short attention span
HP:0000738	Hallucinations

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:2828	young-onset Parkinson disease
OMIM:607060	autosomal dominant Parkinson disease 8
ORPHA:411602	late-onset Parkinson disease

PubChem Disease

GHR Health Conditions

MedGen Diseases

Autosomal dominant Parkinson disease 8

OMIM Phenotypes

PARKINSON DISEASE 8, AUTOSOMAL DOMINANT; PARK8

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

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Last updated: April 6, 2026