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complement C4B (Chido blood group)

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12268

PubChem

12268

Alliance of Genome Resources

MGI:88228

Annotation

Keyword

Cell projection
Cleavage on pair of basic residues
Complement pathway
Disulfide bond
Glycoprotein
Inflammatory response
Reference proteome
Secreted
Signal
Sulfation
Synapse
Thioester bond

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P01029
Q3TYN1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
inflammatory response	IEA
complement activation	IMP	12421924
complement activation	IBA
complement activation, classical pathway	IEA
immunoglobulin mediated immune response	IMP	12421924

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

lymphocyte mediated immunity [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

complement activation

complement activation, classical pathway

activation of immune response [inference]

complement activation

complement activation, classical pathway

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response [inference]

adaptive immune response [inference]

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

B cell mediated immunity [inference]

immunoglobulin mediated immune response

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular space	ISO
extracellular space	IDA	3023818
extracellular space	IBA
extracellular space	HDA	24006456

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

other organism part [inference]

symbiont cell surface

cell body [inference]

neuronal cell body

Displaying **all 4** entries
GO Term	Evidence Code	PMID
complement binding	ISO
complement component C1q complex binding	ISO
endopeptidase inhibitor activity	IEA
carbohydrate binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

opsonin binding [inference]

complement component C1q complex binding

complement binding

complement component C1q complex binding

carbohydrate binding

protein-containing complex binding [inference]

complement component C1q complex binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
endopeptidase inhibitor activity

Displaying **all 5** entries
InterPro
Alpha-2-macroglobulin, bait region domain
Alpha-2-macroglobulin
Alpha-macroglobulin, receptor-binding
Alpha-macroglobulin-like, TED domain
Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	720	Xenbase:XB-GENE-478881	HUMAN84123
Homo sapiens	721	Xenbase:XB-GENE-478881	HUMAN84123
Xenopus tropicalis	12268	Xenbase:XB-GENE-478881
Rattus norvegicus	24233	Xenbase:XB-GENE-478881	RATNO21691
Bos taurus	280678		BOVIN18738
Rattus norvegicus	406161		RATNO21929
Sus scrofa	445467		PIGXX31217
Pan troglodytes	462577		PANTR37782
Canis lupus familiaris	481722		CANLF02580
Danio rerio	566261		DANRE08545

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Annotation

OrthoDB (Group)

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Acknowledgements