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Guidelines

MIRAGE

calnexin

Summary

Gene Symbol

Canx

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12330

KEGG Gene ID

PubChem

12330

Alliance of Genome Resources

MGI:88261

Annotation

Keyword

Acetylation
Calcium
Chaperone
Disulfide bond
Endoplasmic reticulum
Lectin
Metal-binding
Mitochondrion
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P35564
Q5SUC3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein folding	IBA
protein folding	IEA
ERAD pathway	IBA
synaptic vesicle endocytosis	IDA
synaptic vesicle endocytosis	IMP

GO Hierarchy

biological process

cellular process [inference]

protein folding

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
nuclear envelope	IEA
endoplasmic reticulum	ISO
endoplasmic reticulum	IDA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	ISS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

cytoplasm [inference]

neuron projection cytoplasm [inference]

dendrite cytoplasm

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

pigment granule membrane [inference]

melanosome membrane

plasma membrane region [inference]

synaptic membrane [inference]

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle envelope [inference]

nuclear envelope

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron spine [inference]

dendritic spine

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular membraneless organelle [inference]

ribosome

organelle membrane contact site [inference]

mitochondria-associated endoplasmic reticulum membrane contact site

cell body [inference]

neuronal cell body

endoplasmic reticulum quality control compartment

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IBA
calcium ion binding	IEA
protein binding	IPI
carbohydrate binding
apolipoprotein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

glutamate receptor binding [inference]

ionotropic glutamate receptor binding

carbohydrate binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

calnexin

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
calcium ion binding
unfolded protein binding

Displaying **all 4** entries
InterPro
Calreticulin/calnexin, P domain superfamily
Calreticulin/calnexin, conserved site
Calreticulin/calnexin
Concanavalin A-like lectin/glucanase domain superfamily

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	176390	WB:WBGene00000567
Drosophila melanogaster	44643	FB:FBgn0015622
Homo sapiens	821	HGNC:1473
Saccharomyces cerevisiae S288C	851241	SGD:S000000054

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026