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MIRAGE

ectonucleoside triphosphate diphosphohydrolase 2

Summary

Gene Symbol

Entpd2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12496

KEGG Gene ID

PubChem

12496

Alliance of Genome Resources

MGI:1096863

Annotation

Keyword

ATP-binding
Alternative splicing
Calcium
Cell membrane
Disulfide bond
GTP-binding
Glycoprotein
Hydrolase
Magnesium
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O55026	CD39 antigen-like 1 Ecto-ATP diphosphohydrolase 2
Q921R1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	IDA
nucleoside diphosphate metabolic process
nucleoside diphosphate catabolic process	IBA
purine ribonucleoside diphosphate catabolic process	IDA
ribonucleoside diphosphate catabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

signal transduction [inference]

G protein-coupled receptor signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside diphosphate metabolic process

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

purine nucleoside diphosphate metabolic process [inference]

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate metabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate metabolic process [inference]

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

nucleoside phosphate catabolic process [inference]

nucleoside diphosphate catabolic process

purine nucleoside diphosphate catabolic process [inference]

purine ribonucleoside diphosphate catabolic process

ribonucleoside diphosphate catabolic process

purine ribonucleoside diphosphate catabolic process

nucleoside triphosphate catabolic process [inference]

ribonucleoside triphosphate catabolic process

multicellular organismal process [inference]

cell activation [inference]

platelet activation

response to stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to interleukin-6 [inference]

cellular response to interleukin-6

cellular response to cytokine stimulus [inference]

cellular response to interleukin-6

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
basement membrane	IDA
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IDA
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

plasma membrane

plasma membrane region [inference]

cell projection membrane

external encapsulating structure [inference]

extracellular matrix [inference]

basement membrane

cell body

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
GTPase activity	IEA
apyrase activity	ISO
apyrase activity	IDA
apyrase activity	IEA
GDP phosphatase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

apyrase activity

nucleoside diphosphate phosphatase activity

ribonucleoside triphosphate phosphatase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ectonucleoside triphosphate diphosphohydrolase

Functional Category

E: Amino acid transport and metabolism
F: Nucleotide transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
hydrolase activity
nucleotide binding

Displaying 1 entry
InterPro
Nucleoside phosphatase GDA1/CD39

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	64467	RGD:69266
Homo sapiens	954	HGNC:3364

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Last updated: April 6, 2026