GlyCosmos Portal

Submissions

cholesterol 25-hydroxylase

Summary

Gene Symbol

Ch25h

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12642

KEGG Gene ID

PubChem

12642

Alliance of Genome Resources

MGI:1333869

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Monooxygenase
Reference proteome
Sterol biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Z0F5	Cholesterol 25-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
lipid metabolic process	IEA
cholesterol metabolic process	ISO
cholesterol metabolic process	IDA
cholesterol metabolic process	IEA
lipid biosynthetic process	IEA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

sterol biosynthetic process

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

zymosterol metabolic process [inference]

zymosterol biosynthetic process

lipid biosynthetic process

steroid biosynthetic process [inference]

sterol biosynthetic process

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

zymosterol metabolic process [inference]

zymosterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process [inference]

cholesterol biosynthetic process via desmosterol

zymosterol biosynthetic process

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

B cell chemotaxis

response to stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to type I interferon

biological regulation [inference]

regulation of biological process [inference]

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

negative regulation of viral process [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of viral process [inference]

negative regulation of viral process [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of small molecule metabolic process [inference]

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

regulation of cholesterol metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of steroid metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of small molecule metabolic process [inference]

negative regulation of cholesterol metabolic process

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of fusion of virus membrane with host plasma membrane

regulation of fusion of virus membrane with host plasma membrane [inference]

negative regulation of fusion of virus membrane with host plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	EXP
endoplasmic reticulum membrane	IBA
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 11 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
C-4 methylsterol oxidase activity	IBA
cholesterol 25-hydroxylase activity	ISS
cholesterol 25-hydroxylase activity	ISO
cholesterol 25-hydroxylase activity	EXP
cholesterol 25-hydroxylase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

steroid hydroxylase activity

cholesterol 25-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

cholesterol 25-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cholesterol 25-hydroxylase

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 10** entries
Gene Ontology
C-4 methylsterol oxidase activity
C-5 sterol desaturase activity
cholesterol biosynthetic process via lathosterol
ergosterol biosynthetic process
iron ion binding
lipid biosynthetic process
oxidoreductase activity
sphingolipid biosynthetic process
sphingolipid delta-4 desaturase activity
sphingosine hydroxylase activity