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cholinergic receptor, muscarinic 3, cardiac

Summary

Gene Symbol

Chrm3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12671

KEGG Gene ID

[""]

PubChem

12671

Alliance of Genome Resources

MGI:88398

Annotation

Keyword

Cell membrane
Disulfide bond
Endoplasmic reticulum
G-protein coupled receptor
Glycoprotein
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9ERZ3	Mm3 mAChR
Q542R4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
negative regulation of heart rate by acetylcholine	ISO
smooth muscle contraction	IMP
regulation of smooth muscle contraction	IBA
G protein-coupled receptor signaling pathway	IEA
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, cholinergic

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

smooth muscle contraction

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

positive regulation of vascular associated smooth muscle contraction

positive regulation of vasoconstriction

positive regulation of vascular associated smooth muscle contraction

digestive system process [inference]

saliva secretion

secretion by tissue [inference]

saliva secretion

response to stimulus [inference]

response to chemical [inference]

response to nitrogen compound [inference]

response to acetylcholine

response to oxygen-containing compound [inference]

response to acetylcholine

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

body fluid secretion [inference]

saliva secretion

secretion by tissue [inference]

saliva secretion

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, cholinergic

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of vascular associated smooth muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of vascular associated smooth muscle contraction

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate by acetylcholine

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway [inference]

phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction

regulation of vascular associated smooth muscle contraction [inference]

positive regulation of vascular associated smooth muscle contraction

positive regulation of smooth muscle contraction

positive regulation of vascular associated smooth muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of vascular associated smooth muscle contraction

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by chemical signal [inference]

negative regulation of heart rate by acetylcholine

negative regulation of heart rate [inference]

negative regulation of heart rate by acetylcholine

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate by acetylcholine

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

positive regulation of vascular associated smooth muscle contraction

positive regulation of vasoconstriction

positive regulation of vascular associated smooth muscle contraction

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate by acetylcholine

positive regulation of multicellular organismal process [inference]

positive regulation of vasoconstriction

positive regulation of vascular associated smooth muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction

positive regulation of vascular associated smooth muscle contraction

negative regulation of multicellular organismal process [inference]

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of heart rate [inference]

negative regulation of heart rate by acetylcholine

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by chemical signal [inference]

negative regulation of heart rate by acetylcholine

negative regulation of heart rate [inference]

negative regulation of heart rate by acetylcholine

regulation of body fluid levels [inference]

body fluid secretion [inference]

saliva secretion

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

regulation of vascular associated smooth muscle contraction [inference]

positive regulation of vascular associated smooth muscle contraction

positive regulation of vasoconstriction

positive regulation of vascular associated smooth muscle contraction

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	ISO
endoplasmic reticulum membrane	IEA
plasma membrane	ISS
plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

glutamatergic synapse

neuron to neuron synapse [inference]

asymmetric synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor activity	IEA
protein binding	IPI
G protein-coupled acetylcholine receptor activity	ISS
G protein-coupled acetylcholine receptor activity	ISO
G protein-coupled acetylcholine receptor activity	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

G protein-coupled acetylcholine receptor binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

acetylcholine binding

quaternary ammonium group binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

G protein-coupled amine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

acetylcholine receptor activity [inference]

G protein-coupled acetylcholine receptor activity

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled acetylcholine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

muscarinic acetylcholine receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
G protein-coupled acetylcholine receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway