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alcohol dehydrogenase 5 (class III), chi polypeptide

Summary

Gene Symbol

ADH5

Aliases

ADH-3
ADHX
GSNOR
S-nitrosoglutathione reductase

Organism

Homo sapiens (human)

External Links

NCBI Gene

128

HGNC

253

KEGG Gene ID

["hsa:128"]

PubChem

128

Alliance of Genome Resources

HGNC:253

JoGo

ADH5

TogoVar

ADH5

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Disease variant
Dwarfism
Intellectual disability
Lipid metabolism
Metal-binding
NAD
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6IRT1
P11766	Alcohol dehydrogenase 5 Alcohol dehydrogenase class chi chain Alcohol dehydrogenase class-III Glutathione-dependent formaldehyde dehydrogenase S-(hydroxymethyl)glutathione dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
retinoid metabolic process
respiratory system process
fatty acid omega-oxidation	IDA
response to lipopolysaccharide
positive regulation of blood pressure

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

aldehyde catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

catabolic process [inference]

small molecule catabolic process [inference]

formaldehyde catabolic process

aldehyde catabolic process [inference]

formaldehyde catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid oxidation [inference]

fatty acid omega-oxidation

small molecule catabolic process [inference]

formaldehyde catabolic process

formaldehyde metabolic process [inference]

formaldehyde catabolic process

cellular detoxification [inference]

cellular detoxification of aldehyde [inference]

formaldehyde catabolic process

multicellular organismal process [inference]

system process [inference]

respiratory system process

response to stimulus [inference]

response to stress [inference]

response to nitrosative stress

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to redox state

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure [inference]

positive regulation of blood pressure

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde [inference]

formaldehyde catabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA
mitochondrion
cytosol	TAS
cytosol	IBA
extracellular exosome	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
alcohol dehydrogenase (NAD+) activity	EXP
alcohol dehydrogenase (NAD+) activity	IBA
alcohol dehydrogenase (NAD+) activity	IEA
fatty acid binding	IDA
zinc ion binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

alcohol dehydrogenase [NAD(P)+] activity [inference]

alcohol dehydrogenase (NAD+) activity

S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity

S-nitrosoglutathione reductase (NADH) activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NAD+) activity [inference]

formaldehyde dehydrogenase (NAD+) activity

binding [inference]

protein binding [inference]

identical protein binding

lipid binding [inference]

fatty acid binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

fatty acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

monocarboxylic acid binding [inference]

fatty acid binding

electron transfer activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dehydrogenase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
S-(hydroxymethyl)glutathione dehydrogenase activity
alcohol dehydrogenase activity, zinc-dependent
ethanol oxidation
formaldehyde catabolic process
metal ion binding
oxidoreductase activity
zinc ion binding

Displaying **all 6** entries
InterPro
Alcohol dehydrogenase class III
Alcohol dehydrogenase, zinc-type, conserved site
Alcohol dehydrogenase-like, C-terminal
Alcohol dehydrogenase-like, N-terminal
GroES-like superfamily
NAD(P)-binding domain superfamily

Human Protein Atlas

ENSG00000197894

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00121

Name

S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]

References

Rhea

RHEA:19981

NADP⁺ + S-(hydroxymethyl)glutathione

H⁺ + S-formylglutathione + NADPH

Enzyme

1.1.1.284

PMID

RHEA:10740

a secondary alcohol + NAD⁺

H⁺ + a ketone + NADH

Enzyme

1.1.1.1

PMID

RHEA:25290

ethanol + NAD⁺

acetaldehyde + H⁺ + NADH

Enzyme

1.1.1.1

PMID

RHEA:10736

a primary alcohol + NAD⁺

H⁺ + an aldehyde + NADH

Enzyme

PMID

RHEA:19985

NAD⁺ + S-(hydroxymethyl)glutathione

H⁺ + S-formylglutathione + NADH

Enzyme

1.1.1.284

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080952	AMED syndrome	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 19 in total

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HPO ID	HPO Term
HP:0000013	Hypoplasia of the uterus
HP:0000252	Microcephaly
HP:0000268	Dolichocephaly
HP:0000506	Telecanthus
HP:0000729	Autistic behavior
HP:0000835	Adrenal hypoplasia
HP:0000953	Hyperpigmentation of the skin
HP:0001249	Intellectual disability
HP:0001508	Failure to thrive
HP:0001873	Thrombocytopenia