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coatomer protein complex subunit alpha

Summary

Gene Symbol

Copa

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

12847

PubChem

12847

Alliance of Genome Resources

MGI:1334462

Annotation

Keyword

3D-structure
Cytoplasm
Cytoplasmic vesicle
ER-Golgi transport
Golgi apparatus
Hormone
Membrane
Methylation
Phosphoprotein
Protein transport
Reference proteome
Repeat
Secreted
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8CIE6	Alpha-coat protein
Q8BTF0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
intracellular protein transport	IBA
intracellular protein transport	IEA
endoplasmic reticulum to Golgi vesicle-mediated transport	IBA
endoplasmic reticulum to Golgi vesicle-mediated transport	IEA
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

cellular localization [inference]

intracellular transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

pancreatic juice secretion

secretion by tissue [inference]

pancreatic juice secretion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

secretion [inference]

body fluid secretion [inference]

pancreatic juice secretion

secretion by tissue [inference]

pancreatic juice secretion

intracellular transport [inference]

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

cellular localization [inference]

intracellular transport [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

regulation of biological quality [inference]

regulation of body fluid levels [inference]

body fluid secretion [inference]

pancreatic juice secretion

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GO Term	Evidence Code	PMID
Golgi membrane	IEA
extracellular space	ISO
cytoplasm	ISO
Golgi apparatus	ISO	21300694
Golgi apparatus	IDA	21300694

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

vesicle coat [inference]

COPI vesicle coat

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

COPI-coated vesicle

coated vesicle [inference]

COPI-coated vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

COPI-coated vesicle

coated vesicle [inference]

COPI-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

COPI-coated vesicle

coated vesicle [inference]

COPI-coated vesicle

cell body [inference]

neuronal cell body

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mRNA binding	IDA	21300694
hormone activity	IEA
structural molecule activity	IEA
protein binding	IPI	21300694 36792666

GO Hierarchy

molecular function

structural molecule activity

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

hormone activity

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Coatomer

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
intra-Golgi vesicle-mediated transport
structural molecule activity

Displaying **all 7** entries
InterPro
Coatomer, WD associated region
Coatomer, alpha subunit, C-terminal
G-protein beta WD-40 repeat
WD40 repeat, conserved site
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081242	autoimmune interstitial lung, joint, and kidney disease	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1314	Xenbase:XB-GENE-989762	HUMAN53043
Xenopus tropicalis	12847	Xenbase:XB-GENE-989762
Danio rerio	260439		DANRE28844
Rattus norvegicus	304978		RATNO07596
Pan troglodytes	469552		PANTR22739
Canis lupus familiaris	478973		CANLF14436
Macaca mulatta	719683		MACMU23563
Oryctolagus cuniculus	100008878		RABIT03208
Monodelphis domestica	100023010		MONDO15402
Bos taurus	100126041		BOVIN25584

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OrthoDB (Group)

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Acknowledgements