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ER degradation enhancing alpha-mannosidase like protein 2

Summary

Gene Symbol

EDEM2

Organism

Physeter macrocephalus (sperm whale)

External Links

NCBI Gene: 129391321
KEGG Gene ID: ["pcad:129391321"]
PubChem: 129391321

Annotation

Keyword

Calcium
Endoplasmic reticulum
Glycoprotein
Glycosidase
Metal-binding
Reference proteome
Signal
Unfolded protein response

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A2Y9FIB9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
response to unfolded protein
positive regulation of retrograde protein transport, ER to cytosol	IEA
endoplasmic reticulum mannose trimming	IEA
mannose trimming involved in glycoprotein ERAD pathway	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

macromolecule modification [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

response to stimulus [inference]

response to stress [inference]

response to topologically incorrect protein [inference]

response to unfolded protein

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of intracellular protein transport [inference]

regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

regulation of retrograde protein transport, ER to cytosol [inference]

positive regulation of retrograde protein transport, ER to cytosol

positive regulation of intracellular protein transport [inference]

positive regulation of protein exit from endoplasmic reticulum [inference]

positive regulation of retrograde protein transport, ER to cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA
membrane	IEA
endoplasmic reticulum quality control compartment	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

endoplasmic reticulum quality control compartment

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA
calcium ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity [inference]

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mannosyl-oligosaccharide 1,2-alpha-mannosidase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
alpha-mannosidase activity
calcium ion binding
hydrolase activity, acting on glycosyl bonds
hydrolase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
metal ion binding