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serpin family A member 3

Summary

Gene Symbol

SERPINA3

Organism

Homo sapiens (human)

External Links

NCBI Gene

KEGG Gene ID

PubChem

Alliance of Genome Resources

HGNC:16

Annotation

Keyword

3D-structure
Acute phase
Alternative splicing
Direct protein sequencing
Glycoprotein
Proteomics identification
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P01011	Cell growth-inhibiting gene 24/25 protein Serpin A3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
acute-phase response
inflammatory response	NAS
regulation of lipid metabolic process	NAS
maintenance of gastrointestinal epithelium	NAS
response to cytokine	IBA

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

maintenance of gastrointestinal epithelium

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

epithelial structure maintenance [inference]

maintenance of gastrointestinal epithelium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

acute inflammatory response [inference]

acute-phase response

response to chemical [inference]

response to peptide [inference]

response to cytokine

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process

Displaying entries **6 - 10** of 14 in total

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GO Term	Evidence Code	PMID
extracellular region	HDA
obsolete extracellular space
nucleus	TAS
extracellular matrix	HDA
platelet alpha granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
DNA binding	TAS
serine-type endopeptidase inhibitor activity	TAS
serine-type endopeptidase inhibitor activity	IBA
serine-type endopeptidase inhibitor activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

DNA binding

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serpin

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 6** entries
InterPro
Serpin domain
Serpin family
Serpin superfamily, domain 1
Serpin superfamily, domain 2
Serpin superfamily
Serpin, conserved site

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1485	cystic fibrosis	Alliance of Genome Resources
DOID:865	vasculitis	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 11 in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	20717	MGI:98378
Mus musculus	74069	MGI:1921319
Mus musculus	20714	MGI:98377
Mus musculus	238395	MGI:2182843
Mus musculus	16625	MGI:102848
Mus musculus	238393	MGI:2182838
Mus musculus	271047	MGI:2182835
Mus musculus	20716	MGI:105045
Rattus norvegicus	24795	RGD:3747
Rattus norvegicus	24794	RGD:2972

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements