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cathepsin S

Summary

Gene Symbol

Ctss

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13040

KEGG Gene ID

PubChem

13040

Alliance of Genome Resources

MGI:107341

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
regulation of antigen processing and presentation	ISO
regulation of antigen processing and presentation	IEA
proteolysis	ISO
proteolysis	IDA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

proteolysis

protein processing

protein catabolic process

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein catabolic process

protein maturation [inference]

protein processing

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

extracellular matrix disassembly [inference]

basement membrane disassembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly [inference]

basement membrane disassembly

basement membrane organization [inference]

basement membrane disassembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix disassembly [inference]

basement membrane disassembly

basement membrane organization [inference]

basement membrane disassembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of itch

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

response to stimulus [inference]

immune response [inference]

adaptive immune response

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to thyroid hormone [inference]

cellular response to thyroid hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

response to thyroid hormone [inference]

cellular response to thyroid hormone stimulus

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to thyroid hormone stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of antigen processing and presentation

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

regulation of monoatomic cation transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of cation transmembrane transport [inference]

positive regulation of cation channel activity

regulation of molecular function [inference]

regulation of transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity [inference]

positive regulation of cation channel activity

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen [inference]

early endosome lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle [inference]

phagocytic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle [inference]

phagocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

endocytic vesicle [inference]

phagocytic vesicle

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
fibronectin binding	ISO
fibronectin binding	IEA
cysteine-type endopeptidase activity	ISO
cysteine-type endopeptidase activity	EXP
cysteine-type endopeptidase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

binding [inference]

protein binding [inference]

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding [inference]

laminin binding

carbohydrate derivative binding [inference]

proteoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cathepsin S

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity
hydrolase activity
immune response
positive regulation of apoptotic signaling pathway
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 8** entries
InterPro
Cathepsin propeptide inhibitor domain (I29)
Cysteine peptidase, asparagine active site
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Papain-like cysteine endopeptidase
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:11723	Duchenne muscular dystrophy	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	50654	RGD:621513
Homo sapiens	1520	HGNC:2545

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

OrthoDB (Group)

International Collaboration

Acknowledgements