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Guidelines

MIRAGE

dopamine beta hydroxylase

Summary

Gene Symbol

Dbh

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13166

KEGG Gene ID

PubChem

13166

Alliance of Genome Resources

MGI:94864

Annotation

Keyword

3D-structure
Catecholamine biosynthesis
Copper
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Metal-binding
Monooxygenase
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
Q64237	Dopamine beta-monooxygenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
blood vessel remodeling	IMP
response to amphetamine	IMP
leukocyte mediated immunity	IMP
octopamine biosynthetic process
memory	IMP

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity

leukocyte migration

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

amine catabolic process [inference]

biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

octopamine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine catabolic process [inference]

biogenic amine catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

dopamine metabolic process [inference]

dopamine catabolic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catecholamine catabolic process [inference]

dopamine catabolic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound catabolic process [inference]

catechol-containing compound catabolic process [inference]

catecholamine catabolic process [inference]

dopamine catabolic process

phenol-containing compound biosynthetic process [inference]

octopamine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

octopamine metabolic process

octopamine biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

octopamine metabolic process

octopamine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

octopamine biosynthetic process

cell motility [inference]

cell migration [inference]

leukocyte migration

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

visual learning

memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

visual learning

memory

locomotory behavior

visual behavior [inference]

visual learning

reproductive behavior [inference]

parental behavior [inference]

maternal behavior

adult behavior [inference]

behavioral response to ethanol

multicellular organismal response to stress [inference]

tissue remodeling [inference]

blood vessel remodeling

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

homoiothermy

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

homoiothermy

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

response to chemical [inference]

response to nitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

positive regulation of multicellular organismal process [inference]

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

positive regulation of vasoconstriction

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane

secretory granule membrane

chromaffin granule membrane

bounding membrane of organelle [inference]

transport vesicle membrane

secretory granule membrane

chromaffin granule membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

chromaffin granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

chromaffin granule lumen

centriolar satellite

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

varicosity

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

cell body [inference]

neuronal cell body

apical part of cell

presynapse [inference]

terminal bouton

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
catalytic activity	IEA
monooxygenase activity	IEA
dopamine beta-monooxygenase activity	ISS
dopamine beta-monooxygenase activity	ISO
dopamine beta-monooxygenase activity	EXP

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity [inference]

monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

dopamine beta-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

dopamine beta-monooxygenase activity

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090145	dopamine beta-hydroxylase deficiency	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	25699	RGD:2489
Caenorhabditis elegans	181639	WB:WBGene00006541
Drosophila melanogaster	31718	FB:FBgn0010329
Homo sapiens	1621	HGNC:2689

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026