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Guidelines

MIRAGE

DS cell adhesion molecule

Summary

Gene Symbol

Dscam

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13508

KEGG Gene ID

PubChem

13508

Alliance of Genome Resources

MGI:1196281

Annotation

Keyword

Cell adhesion
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurogenesis
Phosphoprotein
Reference proteome
Repeat
Signal
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ERC8	Down syndrome cell adhesion molecule homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 29 in total

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GO Term	Evidence Code	PMID
homophilic cell-cell adhesion	ISS
homophilic cell-cell adhesion	IBA
negative regulation of cell adhesion	IMP
axon guidance	IDA
axon guidance	IGI

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

cell adhesion [inference]

cell-cell adhesion [inference]

homophilic cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

cell recognition [inference]

neuron recognition [inference]

dendrite self-avoidance

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

camera-type eye photoreceptor cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

multicellular organismal process [inference]

behavior [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

post-embryonic animal morphogenesis [inference]

post-embryonic retina morphogenesis in camera-type eye

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

system development [inference]

central nervous system development

dendritic spine development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

photoreceptor cell differentiation [inference]

eye photoreceptor cell differentiation [inference]

camera-type eye photoreceptor cell differentiation

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of response to stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of developmental growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

regulation of phosphorylation [inference]

positive regulation of phosphorylation

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

positive regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis [inference]

positive regulation of axon extension [inference]

positive regulation of axon extension involved in axon guidance

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA
axon	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
cell-cell adhesion mediator activity	IBA
protein tyrosine kinase binding	IPI
netrin receptor binding	ISO
netrin receptor binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

netrin receptor binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

down syndrome cell adhesion molecule-like protein

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 8** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	171119	RGD:619992
Drosophila melanogaster	35652	FB:FBgn0033159
Homo sapiens	1826	HGNC:3039

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Last updated: April 6, 2026