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Guidelines

MIRAGE

desmoglein 2

Summary

Gene Symbol

Dsg2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13511

PubChem

13511

Alliance of Genome Resources

MGI:1196466

Annotation

Keyword

Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Cytoplasm
Glycoprotein
Metal-binding
Palmitate
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O55111

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 46 in total

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GO Term	Evidence Code	PMID
desmosome assembly	IMP
desmosome organization	ISO
desmosome organization	IEA
Purkinje myocyte development	ISO
Purkinje myocyte development	IEA

GO Hierarchy

biological process

cellular process [inference]

cell-cell adhesion

homophilic cell-cell adhesion

homotypic cell-cell adhesion [inference]

cardiac muscle cell-cardiac muscle cell adhesion [inference]

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

heterotypic cell-cell adhesion [inference]

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

cell population proliferation [inference]

stem cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

mesenchymal to epithelial transition

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

desmosome assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

desmosome assembly

cell-cell junction organization [inference]

desmosome organization

desmosome assembly

cell-cell junction assembly [inference]

desmosome assembly

reproductive process [inference]

multicellular organismal reproductive process [inference]

maternal process involved in female pregnancy

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development [inference]

ventricular cardiac muscle tissue development [inference]

Purkinje myocyte development

endocrine pancreas development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

mesenchymal to epithelial transition

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to chemical [inference]

response to hormone [inference]

response to steroid hormone [inference]

response to progesterone

response to lipid [inference]

response to steroid hormone [inference]

response to progesterone

response to oxygen-containing compound [inference]

response to ketone [inference]

response to progesterone

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization

regulation of protein localization to cell-cell junction [inference]

positive regulation of protein localization to cell-cell junction

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion

positive regulation of developmental process [inference]

positive regulation of stem cell population maintenance

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of stem cell population maintenance

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of protein localization [inference]

positive regulation of protein localization to cell-cell junction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to wounding [inference]

negative regulation of inflammatory response to wounding

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial to mesenchymal transition

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

regulation of inflammatory response to wounding [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to stimulus [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to external stimulus [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to wounding [inference]

negative regulation of inflammatory response to wounding

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

regulation of inflammatory response [inference]

negative regulation of inflammatory response [inference]

negative regulation of inflammatory response to wounding

regulation of inflammatory response to wounding [inference]

negative regulation of inflammatory response to wounding

regulation of response to wounding [inference]

regulation of inflammatory response to wounding [inference]

negative regulation of inflammatory response to wounding

negative regulation of response to wounding [inference]

negative regulation of inflammatory response to wounding

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

regulation of endothelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

positive regulation of developmental process [inference]

positive regulation of stem cell population maintenance

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

regulation of endothelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of stem cell population maintenance [inference]

positive regulation of stem cell population maintenance

regulation of cellular process [inference]

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of actin filament-based process [inference]

regulation of actin filament-based movement [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition [inference]

negative regulation of epithelial to mesenchymal transition

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

regulation of endothelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell adhesion

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of epithelial to mesenchymal transition

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle cell contraction [inference]

regulation of ventricular cardiac muscle cell action potential

cardiac conduction [inference]

regulation of heart rate by cardiac conduction

regulation of cardiac conduction

positive regulation of multicellular organismal process [inference]

positive regulation of stem cell population maintenance

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial to mesenchymal transition

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

regulation of endothelial cell differentiation [inference]

negative regulation of endothelial cell differentiation

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of stem cell population maintenance [inference]

positive regulation of stem cell population maintenance

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by cardiac conduction

regulation of membrane potential [inference]

regulation of action potential [inference]

regulation of cardiac muscle cell action potential [inference]

regulation of ventricular cardiac muscle cell action potential

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
extracellular region	IEA
cytoplasm	ISS
cytoplasm	ISO
cytoplasm	IEA
plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

lateral plasma membrane

anchoring junction [inference]

cell-cell junction

desmosome

cell-cell contact zone [inference]

intercalated disc

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IBA
calcium ion binding	IEA
protein homodimerization activity	IDA
protein dimerization activity	ISS
protein dimerization activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity

protein homodimerization activity

cell adhesion molecule binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Desmoglein-1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
calcium ion binding
homophilic cell adhesion via plasma membrane adhesion molecules

Displaying **all 5** entries
InterPro
Cadherin conserved site
Cadherin-like superfamily
Cadherin-like
Catenin binding domain superfamily
Desmosomal cadherin

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050431	arrhythmogenic right ventricular cardiomyopathy	Alliance of Genome Resources
DOID:0060036	intrinsic cardiomyopathy	Alliance of Genome Resources
DOID:0110081	arrhythmogenic right ventricular dysplasia 10	Alliance of Genome Resources

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026