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Guidelines

MIRAGE

eukaryotic translation elongation factor 2

Summary

Gene Symbol

Eef2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

13629

KEGG Gene ID

[""]

PubChem

13629

Alliance of Genome Resources

MGI:95288

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Elongation factor
GTP-binding
Hydrolase
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P58252

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
hematopoietic progenitor cell differentiation	IMP
response to ischemia	IEA
skeletal muscle contraction	IEA
translation	IEA
translational elongation	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation at synapse [inference]

translation at postsynapse

translational elongation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation at synapse [inference]

translation at postsynapse

translational elongation

protein metabolic process [inference]

translation at synapse [inference]

translation at postsynapse

primary metabolic process [inference]

protein metabolic process [inference]

translation at synapse [inference]

translation at postsynapse

cell population proliferation [inference]

glial cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

skeletal muscle contraction

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

response to stimulus [inference]

response to stress [inference]

response to ischemia

response to oxidative stress [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus [inference]

cellular response to brain-derived neurotrophic factor stimulus

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to folic acid

response to xenobiotic stimulus

response to lipid [inference]

response to estradiol

response to nitrogen compound [inference]

response to folic acid

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

response to hydrogen peroxide

response to alcohol [inference]

response to ethanol

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

regulation of cytoplasmic translation [inference]

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of cytoplasmic translation

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GO Term	Evidence Code	PMID
nucleus	IDA
cytoplasm	ISS
cytoplasm	ISO
cytoplasm	IDA
cytoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex

cellular anatomical structure [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

membrane [inference]

plasma membrane

cell junction [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

ribosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

ribosome

postsynapse

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GO Term	Evidence Code	PMID
p53 binding	ISO
p53 binding	IEA
RNA binding	ISO
RNA binding	IEA
translation elongation factor activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

nucleic acid binding [inference]

rRNA binding [inference]

5S rRNA binding

lncRNA binding

protein binding

p53 binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

actin filament binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

translation factor activity [inference]

translation elongation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Elongation FacTor

Functional Category

J: Translation, ribosomal structure and biogenesis
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
GTP binding
nucleotide binding

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InterPro
EF-G domain III/V-like
Elongation Factor G, domain II
Elongation factor EFG, domain V-like
P-loop containing nucleoside triphosphate hydrolase
Ribosomal protein uS5 domain 2-type superfamily
Small GTP-binding protein domain
Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Translation elongation factor EFG/EF2, domain IV
Translation elongation factor EFTu-like, domain 2
Translation protein, beta-barrel domain superfamily

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026