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carboxypeptidase E

Summary

Gene Symbol

CPE

Organism

Homo sapiens (human)

External Links

NCBI Gene

1363

PubChem

1363

Alliance of Genome Resources

HGNC:2303

JoGo

CPE

TogoVar

CPE

Annotation

Keyword

Alternative splicing
Carboxypeptidase
Cleavage on pair of basic residues
Cytoplasmic vesicle
Disease variant
Glycoprotein
Hypogonadotropic hypogonadism
Intellectual disability
Membrane
Metal-binding
Metalloprotease
Obesity
Proteomics identification
Reference proteome
Secreted
Signal
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384N679	Carboxypeptidase H Enkephalin convertase Prohormone-processing carboxypeptidase
P16870	Carboxypeptidase H Enkephalin convertase Prohormone-processing carboxypeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cardiac left ventricle morphogenesis	IMP
proteolysis	IEA
peptide metabolic process	IBA
cell communication	IEA
neuropeptide signaling pathway	NAS

GO Hierarchy

biological process

cellular process [inference]

cell communication

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

metabolic process [inference]

peptide metabolic process

hormone metabolic process [inference]

peptide hormone processing [inference]

insulin processing

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

macromolecule modification [inference]

protein modification process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

protein modification process

protein maturation [inference]

protein processing

signaling receptor ligand precursor processing [inference]

peptide hormone processing [inference]

insulin processing

insulin metabolic process [inference]

insulin processing

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac left ventricle morphogenesis

localization [inference]

macromolecule localization [inference]

intracellular protein localization

protein localization to organelle [inference]

protein localization to secretory granule

protein localization to membrane

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

nitrogen compound transport [inference]

peptide hormone secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

peptide hormone secretion

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

biological regulation [inference]

regulation of biological process [inference]

signaling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

G protein-coupled receptor signaling pathway [inference]

neuropeptide signaling pathway

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion

hormone metabolic process [inference]

peptide hormone processing [inference]

insulin processing

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space
cytoplasm	IEA
Golgi apparatus	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

bounding membrane of organelle [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
carboxypeptidase activity	TAS
carboxypeptidase activity	IEA
metallocarboxypeptidase activity	IBA
metallocarboxypeptidase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity [inference]

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

metallocarboxypeptidase activity

metalloexopeptidase activity [inference]

metallocarboxypeptidase activity

binding [inference]

protein binding

signaling receptor binding [inference]

neurexin family protein binding

cell adhesion molecule binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

carboxypeptidase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
carboxypeptidase activity
metallocarboxypeptidase activity
peptide metabolic process
proteolysis
zinc ion binding

Displaying **all 2** entries
InterPro
Carboxypeptidase-like, regulatory domain superfamily
Peptidase M14, carboxypeptidase A

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources