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exostosin glycosyltransferase 1

Summary

Gene Symbol

Ext1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14042

KEGG Gene ID

mmu:14042

PubChem

14042

Alliance of Genome Resources

MGI:894663

Annotation

Keyword

Disulfide bond
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3V1P4	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase
P97464	Exostosin glycosyltransferase 1 Multiple exostoses protein 1 homolog N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of **113** in total

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GO Term	Evidence Code	PMID
polysaccharide biosynthetic process	ISO
polysaccharide biosynthetic process	IEA
cell morphogenesis	IMP
ossification	ISO
ossification	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity

antigen processing and presentation

leukocyte migration [inference]

mononuclear cell migration [inference]

dendritic cell migration

lymphocyte migration [inference]

lymphocyte migration into lymphoid organs

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

cell adhesion

cell adhesion mediated by integrin

cell-cell adhesion [inference]

leukocyte cell-cell adhesion [inference]

leukocyte adhesion to vascular endothelial cell [inference]

signal transduction [inference]

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

smoothened signaling pathway

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

cell recognition [inference]

neuron recognition [inference]

dendrite self-avoidance

metabolic process [inference]

sulfur compound metabolic process [inference]

sulfation

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

gene expression

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

macromolecule catabolic process [inference]

protein catabolic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

gene expression

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparin proteoglycan metabolic process

heparin proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

protein catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparin proteoglycan metabolic process

heparin proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

protein catabolic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein metabolic process [inference]

proteoglycan metabolic process [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

heparan sulfate proteoglycan metabolic process [inference]

heparan sulfate proteoglycan biosynthetic process

heparin proteoglycan metabolic process

heparin proteoglycan biosynthetic process

chondroitin sulfate proteoglycan metabolic process

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

glycoprotein biosynthetic process

protein O-linked glycosylation [inference]

protein O-linked glycosylation via xylose [inference]

proteoglycan biosynthetic process

heparan sulfate proteoglycan biosynthetic process

cell population proliferation

chondrocyte proliferation

cell growth [inference]

developmental cell growth [inference]

chondrocyte hypertrophy

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

hematopoietic progenitor cell differentiation

hematopoietic stem cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

glandular epithelial cell differentiation

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

mesenchymal cell differentiation [inference]

stem cell differentiation [inference]

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

renal filtration cell differentiation [inference]

podocyte differentiation

cell fate commitment

cell motility [inference]

cell migration [inference]

hematopoietic stem cell migration [inference]

hematopoietic stem cell migration to bone marrow

leukocyte migration [inference]

mononuclear cell migration [inference]

dendritic cell migration

lymphocyte migration [inference]

lymphocyte migration into lymphoid organs

cell division [inference]

stem cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization

cellular component assembly [inference]

protein-containing complex assembly

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance

cell junction organization [inference]

cell-cell junction organization [inference]

tight junction organization

extracellular structure organization [inference]

extracellular matrix organization [inference]

protein-containing complex organization [inference]

protein-containing complex assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

multicellular organismal process [inference]

ossification

replacement ossification [inference]

endochondral ossification

ossification involved in bone maturation

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

system process [inference]

circulatory system process [inference]

heart process [inference]

heart contraction

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

pattern specification process [inference]

regionalization [inference]

specification of animal organ identity [inference]

heart field specification

behavior [inference]

molting cycle process [inference]

hair cycle process

hair follicle morphogenesis

multicellular organismal response to stress [inference]

fear response

multicellular organism growth

organ growth [inference]

bone growth

endochondral bone growth

tissue remodeling [inference]

blood vessel remodeling

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

animal organ morphogenesis [inference]

bone morphogenesis

endochondral bone morphogenesis

membrane bone morphogenesis [inference]

perichondral bone morphogenesis

hair follicle morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

limb joint morphogenesis

embryonic morphogenesis

gastrulation

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

anatomical structure development [inference]

tissue development [inference]

nerve development [inference]

cranial nerve development [inference]

optic nerve development

animal organ development [inference]

brain development

gland development [inference]

cartilage development [inference]

cartilage development involved in endochondral bone morphogenesis

system development [inference]

skeletal system development [inference]

embryonic skeletal system development [inference]

embryonic skeletal joint development

cellular developmental process [inference]

cell differentiation [inference]

chondrocyte differentiation

hematopoietic progenitor cell differentiation

hematopoietic stem cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

glandular epithelial cell differentiation

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

mesenchymal cell differentiation [inference]

stem cell differentiation [inference]

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

glomerular epithelial cell differentiation [inference]

podocyte differentiation

renal filtration cell differentiation [inference]

podocyte differentiation

cell fate commitment

growth [inference]

cell growth [inference]

developmental cell growth [inference]

chondrocyte hypertrophy

developmental growth [inference]

multicellular organism growth

organ growth [inference]

bone growth

endochondral bone growth

developmental cell growth [inference]

chondrocyte hypertrophy

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

homeostasis of number of cells [inference]

hematopoietic stem cell homeostasis

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

bone resorption

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

sodium ion homeostasis

inorganic ion homeostasis [inference]

sodium ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

cellular response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity

acute inflammatory response [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity

response to wounding [inference]

wound healing

multicellular organismal response to stress [inference]

fear response

immune response [inference]

inflammatory response to antigenic stimulus [inference]

acute inflammatory response to antigenic stimulus [inference]

hypersensitivity

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

cellular response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

cellular response to virus

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to light intensity

response to endogenous stimulus [inference]

response to growth factor

cellular response to growth factor stimulus [inference]

response to BMP [inference]

cellular response to BMP stimulus

response to fibroblast growth factor [inference]

cellular response to fibroblast growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to leukemia inhibitory factor

response to nitrogen compound [inference]

response to heparin

response to oxygen-containing compound [inference]

response to heparin

localization [inference]

establishment of localization [inference]

transport [inference]

fluid transport

biological process involved in intraspecies interaction between organisms [inference]

social behavior

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

smoothened signaling pathway

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of biological quality [inference]

regulation of blood pressure

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
Golgi membrane	ISS
Golgi membrane	ISO
Golgi membrane	IEA
endoplasmic reticulum	ISO
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

UDP-N-acetylglucosamine transferase complex

endoplasmic reticulum protein-containing complex [inference]

UDP-N-acetylglucosamine transferase complex

catalytic complex

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

UDP-N-acetylglucosamine transferase complex

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

Golgi membrane

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
acetylglucosaminyltransferase activity	IBA
glucuronosyltransferase activity	IBA
glycosyltransferase activity	IMP
glycosyltransferase activity	IEA
protein homodimerization activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

UDP-glycosyltransferase activity [inference]

acetylglucosaminyltransferase activity

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

glucuronosyltransferase activity

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity

glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

glucuronosyltransferase activity

N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

exostosin

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
heparan sulfate proteoglycan biosynthetic process
transferase activity

Displaying **all 4** entries
InterPro
Exostosin, GT47 domain
Exostosin-like
Glycosyl transferase 64 domain
Nucleotide-diphospho-sugar transferases

KEGG BRITE Database

Orthology

K02366

Name

glucuronyl/N-acetylglucosaminyl transferase EXT1 [EC:2.4.1.224 2.4.1.225]

References

9665133

Reactions

Displaying **all 2** entries
KEGG Reaction	Enzyme	Acceptor	Product
R05935	2.4.1.225	G13581JW	G74553IH
R10138	2.4.1.225	G18844FT	G70244WB

Rhea

RHEA:20908

UDP-α-D-glucuronate

H⁺ + UDP

Enzyme

2.4.1.225

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:206	hereditary multiple exostoses	Alliance of Genome Resources

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	299907	RGD:1587375
Caenorhabditis elegans	178080	WB:WBGene00004360
Drosophila melanogaster	36614	FB:FBgn0265974
Homo sapiens	2131	HGNC:3512
Danio rerio	497279	ZFIN:ZDB-GENE-050211-3
Danio rerio	497280	ZFIN:ZDB-GENE-050211-4
Xenopus tropicalis	448393	Xenbase:XB-GENE-867525

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements