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fibulin 1

Summary

Gene Symbol

Fbln1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14114

KEGG Gene ID

PubChem

14114

Alliance of Genome Resources

MGI:95487

Annotation

Keyword

Alternative splicing
Calcium
Direct protein sequencing
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B2CQD6
Q08879	Basement-membrane protein 90
Q3TWK8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
negative regulation of protein phosphorylation	ISO
negative regulation of cell adhesion	ISO
negative regulation of cell adhesion	IEA
embryo implantation	IEA
positive regulation of gene expression	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, fibrin clot formation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

embryo implantation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

regulation of substrate-dependent cell migration, cell attachment to substrate [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

negative regulation of cell motility

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

regulation of biological process involved in symbiotic interaction [inference]

regulation of transformation of host cell by virus [inference]

negative regulation of transformation of host cell by virus

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of fibroblast proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of locomotion [inference]

negative regulation of cell motility

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of cell population proliferation [inference]

negative regulation of stem cell proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cell motility

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

negative regulation of transformation of host cell by virus

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta production

positive regulation of gene expression

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta production

positive regulation of gene expression

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of cell adhesion [inference]

negative regulation of cell adhesion

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of substrate adhesion-dependent cell spreading [inference]

negative regulation of substrate adhesion-dependent cell spreading

regulation of substrate-dependent cell migration, cell attachment to substrate [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of fibroblast proliferation

negative regulation of cell population proliferation [inference]

negative regulation of stem cell proliferation

regulation of fibroblast proliferation [inference]

positive regulation of fibroblast proliferation

regulation of stem cell proliferation [inference]

negative regulation of stem cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of fibroblast proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

negative regulation of cellular process [inference]

negative regulation of cell adhesion

negative regulation of cell-substrate adhesion [inference]

negative regulation of substrate adhesion-dependent cell spreading

negative regulation of cell population proliferation [inference]

negative regulation of stem cell proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cell motility

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

regulation of substrate-dependent cell migration, cell attachment to substrate [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

negative regulation of cell motility

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of substrate-dependent cell migration, cell attachment to substrate

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	IBA
extracellular region	IEA
extracellular region	HDA
basement membrane	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

basement membrane

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

elastic fiber

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
fibronectin binding	ISO
fibronectin binding	IEA
integrin binding	ISO
integrin binding	IEA
extracellular matrix structural constituent	RCA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

fibronectin binding

signaling receptor binding [inference]

integrin binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

peptidase activator activity

peptidase regulator activity [inference]

peptidase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

peptidase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

fibulin-1

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium ion binding
extracellular matrix organization
peptidase activator activity

Displaying **all 9** entries
InterPro
Anaphylatoxin/fibulin
Complement Clr-like EGF domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Fibulin-1
Growth factor receptor cysteine-rich domain superfamily
NOTCH1 EGF-like calcium-binding domain

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	177788	WB:WBGene00001403
Homo sapiens	2192	HGNC:3600

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements