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MIRAGE
poly(ADP-ribose) polymerase 1
Summary
- Gene Symbol
-
- PARP1
- Aliases
-
- ARTD1
- PARP
- PARS
- Poly-PARP
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- Acetylation
- Allosteric enzyme
- Apoptosis
- Chromosome
- Cytoplasm
- DNA repair
- DNA-binding
- Direct protein sequencing
- Glycosyltransferase
- Innate immunity
- Isopeptide bond
- NAD
- Nucleotidyltransferase
- Nucleus
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- Transcription regulation
- Ubl conjugation
- Zinc-finger
- Proteins
| UniProt | Protein Name |
|---|---|
| P09874 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| single strand break repair |
|
|
| negative regulation of transcription by RNA polymerase II |
|
|
| negative regulation of transcription by RNA polymerase II |
|
|
| telomere maintenance |
|
|
| DNA repair |
|
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of signaling [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of DNA metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of nucleotide metabolic process [inference]
negative regulation of nucleobase-containing compound metabolic process [inference]
regulation of DNA metabolic process [inference]
regulation of RNA metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| membrane |
|
|
| nuclear body |
|
|
| protein-containing complex |
|
|
| protein-DNA complex |
|
|
| site of double-strand break |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| DNA binding |
|
|
| DNA binding |
|
|
| DNA binding |
|
|
| chromatin binding |
|
|
| damaged DNA binding |
|
GO Hierarchy
molecular function
catalytic activity [inference]
transferase activity [inference]
glycosyltransferase activity [inference]
pentosyltransferase activity [inference]
catalytic activity, acting on a protein [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Poly ADP-ribose polymerase
- Functional Category
-
- K: Transcription
- L: Replication, recombination and repair
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| NAD+ ADP-ribosyltransferase activity |
| NAD+-protein ADP-ribosyltransferase activity |
| double-strand break repair |
| nucleotidyltransferase activity |
| transferase activity |
| zinc ion binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:848 | arthritis | |
| DOID:5517 | stomach carcinoma | |
| DOID:2841 | asthma | |
| DOID:417 | autoimmune disease | |
| DOID:10652 | Alzheimer's disease | |
| DOID:14330 | Parkinson's disease | |
| DOID:9470 | bacterial meningitis | |
| DOID:10952 | nephritis |
Ortholog
| Species | Gene ID | Alliance of Genome Resources |
|---|---|---|
| 25591 | RGD:2053 | |
| 266823 | WB:WBGene00004049 | |
| 3355109 | FB:FBgn0010247 | |
| 560788 | ZFIN:ZDB-GENE-030131-3955 |
