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ferritin heavy polypeptide 1

Summary

Gene Symbol

Fth1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14319

KEGG Gene ID

PubChem

14319

Alliance of Genome Resources

MGI:95588

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Iron storage
Lysosome
Metal-binding
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P09528

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
iron ion transport	IDA
iron ion transport	IBA
iron ion transport	IEA
intracellular iron ion homeostasis	IEA
immune response	ISS

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

response to stimulus [inference]

immune response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of fibroblast proliferation

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular process [inference]

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of fibroblast proliferation

regulation of fibroblast proliferation [inference]

negative regulation of fibroblast proliferation

regulation of programmed cell death [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of fibroblast proliferation

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

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GO Term	Evidence Code	PMID
extracellular region	TAS
cytoplasm	ISO
cytoplasm	EXP
cytoplasm	IBA
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endocytic vesicle lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

secondary lysosome [inference]

autolysosome

autophagosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

secondary lysosome [inference]

autolysosome

autophagosome

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
ferroxidase activity	ISS
ferroxidase activity	ISO
ferroxidase activity	IEA
iron ion binding	IDA
ferrous iron binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on metal ions [inference]

oxidoreductase activity, acting on metal ions, oxygen as acceptor [inference]

ferroxidase activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ferritin

Functional Category

M: Cell wall/membrane/envelope biogenesis
P: Inorganic ion transport and metabolism
V: Defense mechanisms

Displaying **all 5** entries
Gene Ontology
ferric iron binding
ferrous iron binding
intracellular iron ion homeostasis
intracellular sequestering of iron ion
metal ion binding

Displaying **all 5** entries
InterPro
Ferritin-like diiron domain
Ferritin-like superfamily
Ferritin-like
Ferritin/DPS protein domain
Ferritin

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	2495	HGNC:3976

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements