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growth differentiation factor 5

Summary

Gene Symbol

Gdf5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14563

PubChem

14563

Alliance of Genome Resources

MGI:95688

Annotation

Keyword

Cell membrane
Chondrogenesis
Cleavage on pair of basic residues
Cytokine
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P43027	Bone morphogenetic protein 14
Q8BRW9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 29 in total

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GO Term	Evidence Code	PMID
positive regulation of neuron differentiation	IEA
negative regulation of epithelial cell proliferation	ISO
negative regulation of epithelial cell proliferation	IEA
positive regulation of SMAD protein signal transduction	ISO
positive regulation of SMAD protein signal transduction	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

mesenchymal cell apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

multicellular organismal process [inference]

ossification [inference]

ossification involved in bone remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

appendage morphogenesis [inference]

limb morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis

embryonic morphogenesis [inference]

embryonic appendage morphogenesis [inference]

embryonic limb morphogenesis

cellular developmental process [inference]

cell differentiation [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of growth [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of cell differentiation [inference]

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cartilage development [inference]

positive regulation of chondrocyte differentiation

positive regulation of multicellular organismal process [inference]

positive regulation of cartilage development [inference]

positive regulation of chondrocyte differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

positive regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

positive regulation of neuron differentiation

regulation of developmental growth [inference]

regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cartilage development [inference]

positive regulation of chondrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

positive regulation of cartilage development [inference]

positive regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway

transforming growth factor beta receptor superfamily signaling pathway [inference]

BMP signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of intracellular signal transduction [inference]

regulation of SMAD protein signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of mesenchymal cell apoptotic process [inference]

negative regulation of mesenchymal cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

regulation of cell differentiation [inference]

regulation of chondrocyte differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

positive regulation of cell differentiation [inference]

regulation of neuron differentiation [inference]

positive regulation of neuron differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of SMAD protein signal transduction

positive regulation of cell differentiation [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of cell differentiation [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth

positive regulation of multicellular organismal process [inference]

positive regulation of cartilage development [inference]

positive regulation of chondrocyte differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

regulation of chondrocyte differentiation [inference]

positive regulation of cartilage development [inference]

positive regulation of chondrocyte differentiation

negative regulation of cartilage development [inference]

negative regulation of chondrocyte differentiation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular space	IBA
extracellular space	IEA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	ISO
cytokine activity	IBA
cytokine activity	IEA
protein binding	IPI	14660436 14973287 15206957
growth factor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

receptor ligand activity [inference]

cytokine binding [inference]

BMP binding

identical protein binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050790	fibular hypoplasia and complex brachydactyly	Alliance of Genome Resources
DOID:0050794	multiple synostoses syndrome	Alliance of Genome Resources
DOID:0080051	acromesomelic dysplasia, Hunter-Thompson type	Alliance of Genome Resources
DOID:0080052	acromesomelic dysplasia, Grebe type	Alliance of Genome Resources
DOID:0110965	brachydactyly type A2	Alliance of Genome Resources
DOID:0110970	brachydactyly type C	Alliance of Genome Resources
DOID:0110977	brachydactyly type A1C	Alliance of Genome Resources
DOID:8398	osteoarthritis	Alliance of Genome Resources

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