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low density lipoprotein receptor-related protein 2

Summary

Gene Symbol

Lrp2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14725

PubChem

14725

Alliance of Genome Resources

MGI:95794

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Cell projection
Coated pit
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Hearing
Metal-binding
Neurogenesis
Phosphoprotein
Receptor
Reference proteome
Repeat
SH3-binding
Signal
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
A2ARV4	Glycoprotein 330 Megalin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 51 in total

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GO Term	Evidence Code	PMID
kidney development	IMP	27002738
neural tube closure	IMP	24639464
secondary heart field specification	IMP	26822476
outflow tract septum morphogenesis	IMP	26822476
outflow tract morphogenesis	IMP	34463328

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

vitamin D metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

vitamin D metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

vitamin D metabolic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

vitamin D metabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process

vitamin D metabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cell population proliferation

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

endocytic hemoglobin import into cell

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular localization [inference]

intracellular transport [inference]

endosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of protein localization [inference]

protein transport

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

transmembrane transport [inference]

vitamin transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

import across plasma membrane [inference]

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

neuron projection arborization

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

female genitalia development [inference]

vagina development

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

pattern specification process [inference]

regionalization [inference]

specification of animal organ identity [inference]

heart field specification [inference]

secondary heart field specification

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

female genitalia development [inference]

vagina development

anatomical structure morphogenesis [inference]

outflow tract morphogenesis

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

neuron projection arborization

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis [inference]

coronary vasculature morphogenesis [inference]

coronary artery morphogenesis

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

ventricular cardiac muscle tissue morphogenesis [inference]

ventricular compact myocardium morphogenesis

cardiac septum morphogenesis [inference]

outflow tract septum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

blood vessel development [inference]

artery development [inference]

aorta development

coronary vasculature development

cardiac septum development [inference]

ventricular septum development

forebrain development

animal organ development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

female genitalia development [inference]

vagina development

reproductive structure development [inference]

gonad development [inference]

male gonad development

genitalia development [inference]

female genitalia development [inference]

vagina development

cranial skeletal system development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

positive chemotaxis [inference]

chemoattraction of axon

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

response to X-ray

response to endogenous stimulus [inference]

response to hormone [inference]

response to leptin

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to leptin

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of protein localization [inference]

protein transport

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

endocytic hemoglobin import into cell

intracellular transport [inference]

endosomal transport

vitamin transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

vitamin transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

transmembrane transport [inference]

vitamin transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

import across plasma membrane [inference]

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

organic substance transport [inference]

protein transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

modified amino acid transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

nitrogen compound transport [inference]

protein transport

amide transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

modified amino acid transport [inference]

folic acid transport [inference]

folate transmembrane transport [inference]

folate import across plasma membrane

import into cell [inference]

endocytosis

receptor-mediated endocytosis

endocytic hemoglobin import into cell

folate import across plasma membrane

establishment of protein localization [inference]

protein transport

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of protein localization [inference]

protein transport

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

regulation of protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

regulation of lipoprotein transport [inference]

positive regulation of lipoprotein transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

regulation of lipoprotein transport [inference]

positive regulation of lipoprotein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

positive regulation of transport [inference]

positive regulation of endocytosis

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of BMP signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of neural precursor cell proliferation [inference]

regulation of oligodendrocyte progenitor proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of BMP signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

regulation of lipoprotein transport [inference]

positive regulation of lipoprotein transport

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of lipoprotein transport

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of gliogenesis [inference]

positive regulation of oligodendrocyte progenitor proliferation

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GO Term	Evidence Code	PMID
extracellular space	ISO
endosome	ISO
endosome	IDA	10766831 12815097
endoplasmic reticulum	IDA	15616221
Golgi apparatus	IDA	15616221

GO Hierarchy

cellular component

protein-containing complex

receptor complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endosome lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

apical part of cell

side of membrane [inference]

external side of plasma membrane

cluster of actin-based cell projections [inference]

brush border

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GO Term	Evidence Code	PMID
calcium ion binding	ISS
calcium ion binding	ISO
protein binding	IPI	10772929 10827173 12508107 15623804 16099815 18174160 19047013 20048263 20637285
nuclear receptor binding	ISO
SH3 domain binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

protein transporter activity

binding [inference]

protein binding

signaling receptor binding [inference]

lipoprotein particle receptor binding [inference]

low-density lipoprotein particle receptor binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

nuclear receptor binding

growth factor binding [inference]

insulin-like growth factor binding [inference]

insulin-like growth factor I binding

protein domain specific binding [inference]

hormone binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding

cargo receptor activity

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

low-density lipoprotein receptor-related protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium ion binding
hormone binding
receptor-mediated endocytosis

Displaying **all 8** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
LDL receptor-like superfamily
LDLR class B repeat
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Six-bladed beta-propeller, TolB-like

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0090144	Donnai-Barrow syndrome	Alliance of Genome Resources
DOID:1062	Fanconi syndrome	Alliance of Genome Resources
DOID:11829	degenerative myopia	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 32** of 32 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Balaenoptera musculus	118898096		BALMU00315
Panthera leo	122226205		PANLE12095

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements