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glutamate receptor, ionotropic, kainate 5 (gamma 2)

Summary

Gene Symbol

Grik5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14809

KEGG Gene ID

PubChem

14809

Alliance of Genome Resources

MGI:95818

Annotation

Keyword

Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q80WU3
Q61626	Glutamate receptor KA-2 Glutamate receptor gamma-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
protein retention in ER lumen	ISO
monoatomic ion transport	IEA
ion transport	IEA
chemical synaptic transmission	ISO
regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization in organelle [inference]

maintenance of protein localization in endoplasmic reticulum [inference]

protein retention in ER lumen

transmembrane transport [inference]

monoatomic ion transmembrane transport

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

establishment of localization in cell

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization in organelle [inference]

maintenance of protein localization in endoplasmic reticulum [inference]

protein retention in ER lumen

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization in organelle [inference]

maintenance of protein localization in endoplasmic reticulum [inference]

protein retention in ER lumen

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

synaptic transmission, glutamatergic

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of vesicle fusion [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane

regulation of synaptic vesicle membrane organization [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane

regulation of vesicle-mediated transport [inference]

regulation of vesicle fusion [inference]

regulation of synaptic vesicle fusion to presynaptic active zone membrane

regulation of biological quality [inference]

regulation of membrane potential

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

regulation of presynaptic membrane potential

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
endoplasmic reticulum	IDA
plasma membrane	ISO
plasma membrane	EXP
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

kainate selective glutamate receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

ionotropic glutamate receptor complex

kainate selective glutamate receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

kainate selective glutamate receptor complex

cation channel complex [inference]

potassium channel complex [inference]

kainate selective glutamate receptor complex

sodium channel complex [inference]

kainate selective glutamate receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

ionotropic glutamate receptor complex

kainate selective glutamate receptor complex

cation channel complex [inference]

potassium channel complex [inference]

kainate selective glutamate receptor complex

sodium channel complex [inference]

kainate selective glutamate receptor complex

cellular anatomical structure [inference]

nucleoplasm

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

cell body [inference]

neuronal cell body

presynapse [inference]

terminal bouton

postsynapse

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
glutamate-gated receptor activity	ISO
glutamate-gated receptor activity	IEA
ion channel activity	IEA
monoatomic ion channel activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

amino acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

kainate selective glutamate receptor activity

sodium channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity

extracellular ligand-gated monoatomic ion channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity [inference]

kainate selective glutamate receptor activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

carboxylic acid transmembrane transporter activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

binding [inference]

protein binding

protein domain specific binding [inference]

identical protein binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity [inference]

glutamate receptor activity

glutamate-gated receptor activity

kainate selective glutamate receptor activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glutamate-gated receptor activity

kainate selective glutamate receptor activity

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GLUTAMATE RECEPTOR

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
ligand-gated monoatomic ion channel activity
modulation of chemical synaptic transmission
monoatomic ion channel activity
monoatomic ion transport
synaptic transmission, glutamatergic
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 6** entries
InterPro
Ionotropic glutamate receptor, C-terminal
Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
Ionotropic glutamate receptor, metazoa
Ionotropic glutamate receptor
Periplasmic binding protein-like I
Receptor, ligand binding region

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	24407	RGD:2735
Caenorhabditis elegans	172449	WB:WBGene00001614
Homo sapiens	2901	HGNC:4583

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements