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Glycomics MS Repository for glycan annotations from GlycoWorkbench

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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

granulin

Summary

Gene Symbol

Grn

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14824

PubChem

14824

Alliance of Genome Resources

MGI:95832

Annotation

Keyword

Cytokine
Direct protein sequencing
Disulfide bond
Glycoprotein
Lysosome
Proteomics identification
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q3U9N4	Acrogranin Proepithelin
P28798	Acrogranin Epithelin/granulin precursor Glycoprotein of 88 Kda PC cell-derived growth factor Proepithelin
Q9D2V3	Acrogranin Proepithelin
Q544Y8	Acrogranin Proepithelin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 64 in total

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GO Term	Evidence Code	PMID
blastocyst hatching	IDA
astrocyte activation involved in immune response	IMP
microglial cell activation involved in immune response	IMP
lysosome organization	IMP
lysosomal transport	ISS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

glial cell activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

astrocyte activation [inference]

astrocyte activation involved in immune response

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

protein catabolic process in the vacuole [inference]

lysosomal protein catabolic process

cell population proliferation [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure

synapse organization [inference]

maintenance of synapse structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure

reproductive process [inference]

embryo implantation

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

mating behavior [inference]

male mating behavior

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

astrocyte activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

leukocyte activation involved in immune response [inference]

macrophage activation involved in immune response [inference]

microglial cell activation involved in immune response

glial cell activation [inference]

microglial cell activation [inference]

microglial cell activation involved in immune response

astrocyte activation [inference]

astrocyte activation involved in immune response

behavior [inference]

locomotory behavior [inference]

locomotory exploration behavior

reproductive behavior [inference]

mating behavior [inference]

male mating behavior

exploration behavior [inference]

locomotory exploration behavior

organism emergence from protective structure [inference]

hatching [inference]

blastocyst hatching

developmental process [inference]

anatomical structure development [inference]

retina development in camera-type eye

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

response to stimulus [inference]

response to chemical [inference]

response to lipid [inference]

response to estradiol

response to oxygen-containing compound [inference]

response to estradiol

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

intracellular transport [inference]

vacuolar transport [inference]

lysosomal transport

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of protein folding

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of endothelial cell migration

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of axon regeneration

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of response to wounding [inference]

positive regulation of developmental process [inference]

positive regulation of dendritic spine development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of immune effector process [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of respiratory burst involved in inflammatory response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of response to external stimulus [inference]

positive regulation of axon regeneration

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of axon regeneration [inference]

positive regulation of axon regeneration

regulation of inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response to wounding [inference]

positive regulation of inflammatory response to wounding

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of axon regeneration

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of response to wounding [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

positive regulation of defense response to bacterium

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response

negative regulation of inflammatory response

negative regulation of respiratory burst involved in inflammatory response

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

positive regulation of inflammatory response [inference]

positive regulation of inflammatory response to wounding

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of inflammatory response to wounding [inference]

positive regulation of inflammatory response to wounding

regulation of neuroinflammatory response [inference]

negative regulation of neuroinflammatory response [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of response to wounding [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

regulation of inflammatory response to wounding [inference]

positive regulation of inflammatory response to wounding

positive regulation of response to wounding [inference]

regulation of developmental process

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

regulation of cell differentiation [inference]

regulation of cell development [inference]

negative regulation of respiratory burst involved in inflammatory response

positive regulation of developmental process [inference]

positive regulation of dendritic spine development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of dendritic spine development [inference]

positive regulation of dendritic spine development

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of respiratory burst [inference]

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cell differentiation [inference]

regulation of cell development [inference]

negative regulation of respiratory burst involved in inflammatory response

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

positive regulation of protein folding

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of respiratory burst [inference]

negative regulation of respiratory burst involved in inflammatory response

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

regulation of vacuole organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

regulation of lysosome organization

positive regulation of lysosome organization

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of lysosome organization

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of cellular response to stress [inference]

regulation of neuron projection regeneration [inference]

regulation of axon regeneration [inference]

positive regulation of axon regeneration

positive regulation of neuron projection regeneration [inference]

positive regulation of axon regeneration

regulation of protein folding [inference]

positive regulation of protein folding

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

regulation of macrophage activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

regulation of microglial cell activation [inference]

negative regulation of microglial cell activation

regulation of neutrophil activation [inference]

negative regulation of neutrophil activation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of macrophage activation [inference]

negative regulation of microglial cell activation

negative regulation of neutrophil activation

negative regulation of respiratory burst involved in inflammatory response

regulation of respiratory burst involved in inflammatory response [inference]

negative regulation of respiratory burst involved in inflammatory response

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of biological quality [inference]

regulation of protein stability [inference]

protein stabilization

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

negative regulation of hydrolase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of aspartic-type peptidase activity

Displaying entries **1 - 5** of 38 in total

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	EXP
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

cell junction [inference]

excitatory synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

glutamatergic synapse

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

neuron to neuron synapse [inference]

asymmetric synapse [inference]

asymmetric, glutamatergic, excitatory synapse [inference]

cerebellar climbing fiber to Purkinje cell synapse

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

late endosome

presynapse

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytokine activity
protein binding	IPI
protein-folding chaperone binding	ISS
protein-folding chaperone binding	ISO
protein-folding chaperone binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-folding chaperone binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

granulin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of inflammatory response

Displaying **all 3** entries
InterPro
Granulin family
Granulin superfamily
Granulin

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060672	frontotemporal dementia 2	Alliance of Genome Resources
DOID:12387	nephrogenic diabetes insipidus	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026