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Guidelines

MIRAGE

glutathione synthetase

Summary

Gene Symbol

Gss

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

14854

KEGG Gene ID

PubChem

14854

Alliance of Genome Resources

MGI:95852

Annotation

Keyword

ATP-binding
Acetylation
Glutathione biosynthesis
Ligase
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q3UEE2
P51855	Glutathione synthase
Q541E2	Glutathione synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glutathione biosynthetic process	ISO
glutathione biosynthetic process	IBA
glutathione biosynthetic process	IEA
response to cadmium ion	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

modified amino acid metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

biosynthetic process [inference]

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

response to stimulus [inference]

response to chemical [inference]

response to metal ion [inference]

response to cadmium ion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	ISS
magnesium ion binding	ISO
magnesium ion binding	IEA
glutathione synthase activity	ISS
glutathione synthase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity

ligase activity, forming carbon-nitrogen bonds [inference]

acid-amino acid ligase activity [inference]

glutathione synthase activity

non-ribosomal peptide synthetase activity [inference]

glutathione synthase activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

amino acid binding [inference]

glycine binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

glycine binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

glutathione binding

cation binding [inference]

glycine binding

metal ion binding [inference]

magnesium ion binding

organic acid binding [inference]

carboxylic acid binding [inference]

glycine binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

peptide binding

modified amino acid binding [inference]

glutathione binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

oligopeptide binding [inference]

glutathione binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

sulfur compound binding [inference]

glutathione binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Glutathione synthetase

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 7** entries
Gene Ontology
ATP binding
glutathione binding
glutathione biosynthetic process
glutathione synthase activity
ligase activity
metal ion binding
nucleotide binding

Displaying **all 7** entries
InterPro
Glutathione synthase, C-terminal, eukaryotic
Glutathione synthase, N-terminal, eukaryotic
Glutathione synthase, alpha-helical
Glutathione synthase, substrate-binding domain superfamily
Glutathione synthase, substrate-binding domain
Glutathione synthase
Pre-ATP-grasp domain superfamily

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026