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cystathionine gamma-lyase

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

1491

PubChem

1491

Alliance of Genome Resources

HGNC:2501

JoGo

CTH

TogoVar

CTH

Annotation

Keyword

3D-structure
Alternative splicing
Calmodulin-binding
Cysteine biosynthesis
Cytoplasm
Disease variant
Lipid metabolism
Lyase
Proteomics identification
Pyridoxal phosphate
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P32929	Cysteine desulfhydrase Cysteine-protein sulfhydrase Gamma-cystathionase Homocysteine desulfhydrase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
obsolete cysteine metabolic process
lipid metabolic process
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	IDA	19019829
obsolete L-cysteine biosynthetic process via L-cystathionine
L-cysteine biosynthetic process	IDA	10212249 19428278

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

endoplasmic reticulum unfolded protein response

metabolic process [inference]

sulfur compound metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

hydrogen sulfide biosynthetic process

hydrogen sulfide metabolic process [inference]

hydrogen sulfide biosynthetic process

biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

sulfur compound biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

hydrogen sulfide biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein-pyridoxal-5-phosphate linkage [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein sulfhydration

macromolecule modification [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein-pyridoxal-5-phosphate linkage [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein sulfhydration

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid metabolic process [inference]

transsulfuration

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

L-amino acid metabolic process [inference]

transsulfuration

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

lipid metabolic process

protein metabolic process [inference]

protein modification process [inference]

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein-pyridoxal-5-phosphate linkage [inference]

protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine

protein sulfhydration

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

sulfur amino acid metabolic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

homocysteine metabolic process [inference]

transsulfuration

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid metabolic process [inference]

transsulfuration

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

non-proteinogenic amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

alpha-amino acid metabolic process [inference]

homocysteine metabolic process [inference]

transsulfuration

L-amino acid metabolic process [inference]

transsulfuration

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

sulfur amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

L-amino acid biosynthetic process [inference]

L-cysteine biosynthetic process

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of vascular associated smooth muscle cell differentiation [inference]

regulation of aortic smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

endoplasmic reticulum unfolded protein response

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

negative regulation of apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of muscle cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of smooth muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

regulation of vascular associated smooth muscle cell differentiation [inference]

regulation of aortic smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell differentiation [inference]

positive regulation of muscle cell differentiation [inference]

positive regulation of smooth muscle cell differentiation [inference]

positive regulation of vascular associated smooth muscle cell differentiation [inference]

positive regulation of aortic smooth muscle cell differentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of apoptotic signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of apoptotic signaling pathway

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA	http://purl.obolibrary.org/obo/go/references/0000044
cytosol	TAS	https://reactome.org/content/detail/R-HSA-1614567 https://reactome.org/content/detail/R-HSA-1614583 https://reactome.org/content/detail/R-HSA-1614591 https://reactome.org/content/detail/R-HSA-1614614 https://reactome.org/content/detail/R-HSA-1614631
cytosol	IEA	http://purl.obolibrary.org/obo/go/references/0000107
extracellular exosome	HDA	19056867

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cystathionine gamma-lyase activity	IDA	10212249 19019829 19428278
cystathionine gamma-lyase activity	IBA	http://purl.obolibrary.org/obo/go/references/0000033
cystathionine gamma-lyase activity	IEA	http://purl.obolibrary.org/obo/go/references/0000107 http://purl.obolibrary.org/obo/go/references/0000116
protein binding	IPI	22169477 25416956 32296183
calmodulin binding

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-sulfur lyase activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cystathionine gamma-lyase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
L-cysteine desulfhydrase activity
L-cystine L-cysteine-lyase (deaminating)
carbon-sulfur lyase activity
cysteine biosynthetic process
pyridoxal phosphate binding
transsulfuration

Displaying **all 4** entries
InterPro
Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
Pyridoxal phosphate-dependent transferase, major domain
Pyridoxal phosphate-dependent transferase, small domain
Pyridoxal phosphate-dependent transferase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0090142	cystathioninuria	Alliance of Genome Resources
DOID:9252	amino acid metabolic disorder	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements