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hyaluronan synthase 1

Summary

Gene Symbol

Has1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15116

KEGG Gene ID

mmu:15116

PubChem

15116

Alliance of Genome Resources

MGI:106590

Annotation

Keyword

Direct protein sequencing
Glycoprotein
Glycosyltransferase
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q61647	Hyaluronate synthase 1 Hyaluronic acid synthase 1
Q3UUP6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
polysaccharide biosynthetic process	IDA
polysaccharide biosynthetic process	IBA
glycosaminoglycan biosynthetic process	IEA
negative regulation of fibroblast migration	ISO
hyaluronan biosynthetic process	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

hyaluronan biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

hyaluronan biosynthetic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

hyaluronan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

hyaluronan biosynthetic process

hyaluronan metabolic process [inference]

hyaluronan biosynthetic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

hyaluronan biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

hyaluronan biosynthetic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process

hyaluronan biosynthetic process

hyaluronan metabolic process [inference]

hyaluronan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process

hyaluronan biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

reproductive process [inference]

multicellular organismal reproductive process [inference]

ovulation cycle [inference]

estrous cycle

rhythmic process [inference]

ovulation cycle [inference]

estrous cycle

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

response to platelet-derived growth factor [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

negative regulation of fibroblast migration

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of fibroblast migration [inference]

negative regulation of fibroblast migration

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of fibroblast migration

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA
cytoplasm	IEA
Golgi apparatus	ISO
plasma membrane	ISO
plasma membrane	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

UDP-N-acetylglucosamine transferase complex

endoplasmic reticulum protein-containing complex [inference]

UDP-N-acetylglucosamine transferase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

UDP-N-acetylglucosamine transferase complex

cellular anatomical structure [inference]

cytoplasm

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
identical protein binding	ISO
hyaluronan synthase activity	IDA
hyaluronan synthase activity	IBA
hyaluronan synthase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

hyaluronan synthase activity

hexosyltransferase activity [inference]

hyaluronan synthase activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00752

Name

hyaluronan synthase [EC:2.4.1.212]

References

8366070

Rhea

RHEA:20465

UDP-N-acetyl-α-D-glucosamine

H⁺ + UDP

Enzyme

2.4.1.212

PMID

RHEA:12528

UDP-α-D-glucuronate

H⁺ + UDP

Enzyme

2.4.1.212

PMID

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	282821	RGD:708528
Homo sapiens	3036	HGNC:4818
Danio rerio	403130	ZFIN:ZDB-GENE-040218-2
Xenopus tropicalis	100491673	Xenbase:XB-GENE-961588

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements