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adrenoceptor beta 1

Summary

Gene Symbol

ADRB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

153

PubChem

153

Alliance of Genome Resources

HGNC:285

Annotation

Keyword

3D-structure
Cell membrane
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Palmitate
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P08588	Beta-1 adrenoreceptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
positive regulation of heart rate by epinephrine-norepinephrine	IEA
positive regulation of the force of heart contraction by epinephrine-norepinephrine	IEA
diet induced thermogenesis	IEA
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA
response to cold	IEA

GO Hierarchy

biological process

metabolic process [inference]

adaptive thermogenesis [inference]

diet induced thermogenesis

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation [inference]

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

multicellular organismal response to stress [inference]

fear response

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

heat generation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

heat generation

response to stimulus [inference]

response to stress [inference]

response to cold

multicellular organismal response to stress [inference]

fear response

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of circadian rhythm [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction [inference]

regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

regulation of heart rate [inference]

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

regulation of behavior [inference]

regulation of circadian sleep/wake cycle [inference]

regulation of circadian sleep/wake cycle, sleep

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of blood circulation [inference]

positive regulation of heart contraction [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of the force of heart contraction [inference]

regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by chemical signal [inference]

positive regulation of the force of heart contraction by epinephrine-norepinephrine

regulation of heart rate [inference]

positive regulation of heart rate [inference]

positive regulation of heart rate by epinephrine-norepinephrine

regulation of blood pressure [inference]

negative regulation of blood pressure [inference]

negative regulation of systemic arterial blood pressure [inference]

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation [inference]

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
early endosome	IDA	21540189
plasma membrane	TAS
plasma membrane	IDA	10212248 11526121 21540189
plasma membrane	IBA
Schaffer collateral - CA1 synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
beta-adrenergic receptor activity	TAS	8892658
beta1-adrenergic receptor activity	IDA	10212248 12391161
beta1-adrenergic receptor activity	IBA
protein binding	IPI	12391161 16316992 16533813 23291003 23381222
PDZ domain binding	IPI	11526121

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

adrenergic receptor binding [inference]

alpha-2A adrenergic receptor binding

protein domain specific binding [inference]

PDZ domain binding

protein dimerization activity [inference]

protein heterodimerization activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

adrenergic receptor activity [inference]

beta-adrenergic receptor activity

beta1-adrenergic receptor activity

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

neurotransmitter receptor activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

G protein-coupled neurotransmitter receptor activity [inference]

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2B adrenergic receptor

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
adrenergic receptor activity
adrenergic receptor signaling pathway
alpha2-adrenergic receptor activity
epinephrine binding

Displaying **all 3** entries
InterPro
Adrenoceptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0050848	obstructive sleep apnea	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11664	nephrosclerosis	Alliance of Genome Resources
DOID:13544	low tension glaucoma	Alliance of Genome Resources
DOID:3083	chronic obstructive pulmonary disease	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources
DOID:824	periodontitis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 49 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	153	ZFIN:ZDB-GENE-081022-145
Drosophila melanogaster	154	FB:FBgn0038063
Drosophila melanogaster	155	FB:FBgn0038063
Mus musculus	11554	ZFIN:ZDB-GENE-081022-145	MOUSE24973
Drosophila melanogaster	11555	FB:FBgn0038063
Drosophila melanogaster	11556	FB:FBgn0038063
Drosophila melanogaster	15562	FB:FBgn0038063
Rattus norvegicus	24925	ZFIN:ZDB-GENE-081022-145	RATNO19361
Drosophila melanogaster	25324	FB:FBgn0038063
Drosophila melanogaster	25645	FB:FBgn0038063

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OrthoDB (Group)

International Collaboration

Acknowledgements