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Guidelines

MIRAGE

cytochrome P450 family 1 subfamily A member 1

Summary

Gene Symbol

CYP1A1

Aliases

CP11
P1-450
P450-C
P450DX

Organism

Homo sapiens (human)

External Links

NCBI Gene

1543

HGNC

2595

KEGG Gene ID

["hsa:1543"]

PubChem

1543

Alliance of Genome Resources

HGNC:2595

JoGo

CYP1A1

TogoVar

CYP1A1

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Fatty acid metabolism
Glycoprotein
Heme
Lipid metabolism
Lyase
Membrane
Microsome
Mitochondrion inner membrane
Monooxygenase
Proteomics identification
Reference proteome
Steroid biosynthesis

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P04798	Cytochrome P450 form 6 Cytochrome P450-C Cytochrome P450-P1 Hydroperoxy icosatetraenoate dehydratase
A0N0X8
E7EMT5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 58 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEA
long-chain fatty acid metabolic process	IDA
liver development	IEA
lipid hydroxylation	IDA
fatty acid metabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process

insecticide metabolic process

xenobiotic catabolic process

dibenzo-p-dioxin catabolic process

catabolic process [inference]

lipid catabolic process [inference]

steroid catabolic process

xenobiotic catabolic process

dibenzo-p-dioxin catabolic process

small molecule catabolic process [inference]

dibenzo-p-dioxin catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

steroid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

secondary metabolic process [inference]

toxin metabolic process

insecticide metabolic process

phenylpropanoid metabolic process [inference]

coumarin metabolic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process

hormone metabolic process

retinoic acid metabolic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

fatty acid metabolic process

long-chain fatty acid metabolic process

arachidonate metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonate metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

steroid metabolic process

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

steroid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

lipid catabolic process [inference]

steroid catabolic process

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process

retinol metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonate metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

long-chain fatty acid metabolic process

arachidonate metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

unsaturated fatty acid metabolic process [inference]

arachidonate metabolic process [inference]

retinoic acid metabolic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

dibenzo-p-dioxin metabolic process

dibenzo-p-dioxin catabolic process

small molecule catabolic process [inference]

dibenzo-p-dioxin catabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

hydrocarbon metabolic process [inference]

olefin metabolic process [inference]

ethylene metabolic process

olefinic compound metabolic process

arachidonate metabolic process [inference]

retinol metabolic process

olefin metabolic process [inference]

ethylene metabolic process

reactive nitrogen species metabolic process [inference]

nitric oxide metabolic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

hepatocyte differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to copper ion

reproductive process [inference]

multicellular organismal reproductive process [inference]

maternal process involved in parturition

multicellular organismal process [inference]

tissue remodeling

developmental process [inference]

anatomical structure development [inference]

tube development [inference]

digestive tract development

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development

gland development [inference]

liver development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

hepatocyte differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to nematode

response to stimulus [inference]

response to stress [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to nematode

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to nematode

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to increased oxygen levels [inference]

response to hyperoxia

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin A

response to food

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin A

response to xenobiotic stimulus

response to toxic substance [inference]

response to herbicide

response to metal ion [inference]

response to iron ion [inference]

response to iron(III) ion

response to copper ion [inference]

cellular response to copper ion

cellular response to metal ion [inference]

cellular response to copper ion

response to food

response to lipid [inference]

response to arsenic-containing substance

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to copper ion

response to phenylpropanoid [inference]

response to hydroxyisoflavone [inference]

response to genistein

response to oxygen-containing compound [inference]

response to lipopolysaccharide

response to ether [inference]

response to diphenyl ether

response to ketone [inference]

response to hydroxyisoflavone [inference]

response to genistein

response to polycyclic arene [inference]

response to 3-methylcholanthrene

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to metal ion [inference]

cellular response to copper ion

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process

retinoic acid metabolic process [inference]

retinoic acid biosynthetic process [inference]

9-cis-retinoic acid biosynthetic process

9-cis-retinoic acid metabolic process [inference]

9-cis-retinoic acid biosynthetic process

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GO Term	Evidence Code	PMID
cytoplasm	IEA
mitochondrion	IBA
mitochondrion	HTP
mitochondrial inner membrane	ISS
mitochondrial inner membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	TAS
monooxygenase activity	IEA
iron ion binding	IEA
protein binding	IPI
arachidonate monooxygenase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

arachidonate monooxygenase activity

steroid hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

flavonoid 3'-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

fatty acid omega-hydroxylase activity [inference]

long-chain fatty acid omega-hydroxylase activity

fatty acid omega-1 hydroxylase activity [inference]

long-chain fatty acid omega-1 hydroxylase activity

oxidoreductase activity, acting on diphenols and related substances as donors

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

arachidonate monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

flavonoid 3'-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

fatty acid omega-hydroxylase activity [inference]

long-chain fatty acid omega-hydroxylase activity

fatty acid omega-1 hydroxylase activity [inference]

long-chain fatty acid omega-1 hydroxylase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

hydroperoxy icosatetraenoate dehydratase activity

demethylase activity

binding [inference]

protein binding

enzyme binding

heat shock protein binding [inference]

protein-folding chaperone binding [inference]

Hsp70 protein binding

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cytochrome P450

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

KEGG BRITE Database

Orthology

K07408

Name

cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]

References

Rhea

(12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

H₂O + 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate

Enzyme

4.2.1.152

PMID

12881489

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

H₂O + 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate

Enzyme

4.2.1.152

PMID

a hydroperoxyeicosatetraenoate

an oxoeicosatetraenoate + H₂O

Enzyme

4.2.1.152

PMID

(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate

H₂O + 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate

Enzyme

4.2.1.152

PMID

17045234

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

H₂O + 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate

Enzyme

4.2.1.152

PMID

12881489

(8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate

H₂O + 8-oxo-(5Z,9E,11Z,14Z)-eicosatetraenoate

Enzyme

4.2.1.152

PMID

17045234

Disease

Disease Ontology

Displaying entries **1 - 10** of 39 in total

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DO ID	Disease Name	Source
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:10892	hypospadias	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:11612	polycystic ovary syndrome	Alliance of Genome Resources
DOID:11836	clubfoot	Alliance of Genome Resources
DOID:11934	head and neck cancer	Alliance of Genome Resources
DOID:12361	Graves' disease	Alliance of Genome Resources
DOID:12894	Sjogren's syndrome	Alliance of Genome Resources

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Acknowledgements

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Last updated: April 6, 2026