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ATP binding cassette subfamily G member 8

Summary

Gene Symbol

Abcg8

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

155192

PubChem

155192

Alliance of Genome Resources

RGD:620300

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Glycoprotein
Lipid transport
Magnesium
Metal-binding
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P58428	Sterolin-2
A6H9I7	Sterolin-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
response to nutrient	IEP	15710224
response to xenobiotic stimulus	IEP	17109865
negative regulation of intestinal phytosterol absorption	ISO
response to muscle activity	IEP	23117815
phospholipid transport	ISO

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

acylglycerol homeostasis [inference]

triglyceride homeostasis

sterol homeostasis

cholesterol homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to nutrient

response to activity [inference]

response to muscle activity

response to chemical [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport

organic substance transport [inference]

lipid transport [inference]

phospholipid transport

sterol transport

cholesterol transport [inference]

cholesterol efflux

organophosphate ester transport [inference]

phospholipid transport

organic hydroxy compound transport [inference]

sterol transport

cholesterol transport [inference]

cholesterol efflux

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of sterol transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of cholesterol transport [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of sterol transport [inference]

negative regulation of cholesterol transport [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal absorption [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

regulation of intestinal lipid absorption [inference]

regulation of intestinal cholesterol absorption [inference]

negative regulation of intestinal cholesterol absorption

negative regulation of intestinal lipid absorption [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of digestive system process [inference]

negative regulation of intestinal absorption [inference]

negative regulation of intestinal lipid absorption [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	IBA
apical plasma membrane	ISS
apical plasma membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

ATP-binding cassette (ABC) transporter complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
ATP binding	ISO
ATP hydrolysis activity	ISO
ATPase-coupled transmembrane transporter activity	ISS
ATPase-coupled transmembrane transporter activity	ISO
ATPase-coupled transmembrane transporter activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

sterol transporter activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

lipid transfer activity [inference]

sterol transfer activity [inference]

cholesterol transfer activity

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ABC transporter G family member

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ABC-type transporter activity
ATP binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter family G domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
ABC-2 type transporter, transmembrane domain
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **41 - 50** of 69 in total

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Species	Gene ID	Orthologous MAtrix
Astyanax mexicanus	103023216	ASTMX10592
Callorhinchus milii	103180802	CALMI21183
Chlorocebus sabaeus	103220381	CHLSB04352
Carlito syrichta	103260470	CARSF14667
Ursus maritimus	103671214	URSMA00095
Nannospalax galili	103725768	NANGA00631
Serinus canaria	103817092	SERCA02181
Rhinopithecus roxellana	104677525	RHIRO22404
Pteropus vampyrus	105292977	PTEVA09969
Macaca nemestrina	105464936	MACNE00834

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LM-GlycoRepo

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OrthoDB (Group)

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