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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

perlecan (heparan sulfate proteoglycan 2)

Summary

Gene Symbol

Hspg2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

15530

KEGG Gene ID

PubChem

15530

Alliance of Genome Resources

MGI:96257

Annotation

Keyword

3D-structure
Angiogenesis
Basement membrane
Calcium
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Heparan sulfate
Immunoglobulin domain
Laminin EGF-like domain
Metal-binding
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q05793	Perlecan
Q2XQV0
E9PZ16
Q3UHH3
Q52KG8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
angiogenesis
response to hypoxia
positive regulation of endothelial cell proliferation	ISO
endochondral ossification	IMP
chondrocyte differentiation	IMP

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular developmental process [inference]

cell differentiation

chondrocyte differentiation

cell development [inference]

neuron development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

reproductive process [inference]

embryo implantation

multicellular organismal process [inference]

ossification [inference]

replacement ossification [inference]

endochondral ossification

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis

skeletal system morphogenesis [inference]

embryonic skeletal system morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic skeletal system morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

cell development [inference]

neuron development

system development [inference]

circulatory system development

animal gross anatomical part developmental process [inference]

tissue development

muscle tissue development [inference]

striated muscle tissue development [inference]

cardiac muscle tissue development

animal organ development [inference]

cartilage development [inference]

cartilage development involved in endochondral bone morphogenesis

circulatory system development

cellular developmental process [inference]

cell differentiation

chondrocyte differentiation

cell development [inference]

neuron development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

macromolecule localization [inference]

intracellular protein localization

protein localization to cell junction [inference]

protein localization to synapse

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic

negative regulation of synaptic transmission, cholinergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

smoothened signaling pathway

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, cholinergic

negative regulation of synaptic transmission, cholinergic

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

regulation of cell adhesion [inference]

negative regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

negative regulation of cell population proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of amyloid fibril formation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

negative regulation of synaptic transmission, cholinergic

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of supramolecular fiber organization [inference]

negative regulation of supramolecular fiber organization [inference]

negative regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

negative regulation of amyloid fibril formation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
microfibril	TAS
extracellular region	ISS
extracellular region	ISO
extracellular region	TAS
extracellular region	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

cell junction [inference]

synapse

external encapsulating structure [inference]

extracellular matrix

basement membrane

gel phase of basement membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

microfibril

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protease binding	IPI
dystroglycan binding	IDA
calcium ion binding	IEA
protein binding	IPI
extracellular matrix structural constituent conferring compression resistance	RCA

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

extracellular matrix structural constituent conferring compression resistance

binding [inference]

protein binding

dystroglycan binding

enzyme binding [inference]

protease binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

protein-containing complex binding [inference]

collagen binding [inference]

collagen V binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0090005	Schwartz-Jampel syndrome 1	Alliance of Genome Resources
DOID:0090032	Silverman-Handmaker type dyssegmental dysplasia	Alliance of Genome Resources
DOID:0060770	dextro-looped transposition of the great arteries	Alliance of Genome Resources
DOID:13481	thanatophoric dysplasia	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	3339	HGNC:5273
Caenorhabditis elegans	175126	WB:WBGene00006787
Drosophila melanogaster	45320	FB:FBgn0284408

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026