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adrenoceptor beta 3

Summary

Gene Symbol

ADRB3

Organism

Homo sapiens (human)

External Links

NCBI Gene

155

PubChem

155

Alliance of Genome Resources

HGNC:288

Annotation

Keyword

Cell membrane
Diabetes mellitus
Disulfide bond
G-protein coupled receptor
Glycoprotein
Obesity
Palmitate
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A8KAG8	Beta-3 adrenoreceptor
P13945	Beta-3 adrenoreceptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
diet induced thermogenesis	IEA
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA
carbohydrate metabolic process	TAS	2570461
generation of precursor metabolites and energy	TAS	2570461
energy reserve metabolic process	TAS	1718744

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

adaptive thermogenesis [inference]

diet induced thermogenesis

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation [inference]

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

behavior [inference]

feeding behavior [inference]

eating behavior

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

heat generation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

fat cell differentiation [inference]

brown fat cell differentiation

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis [inference]

heat generation

response to stimulus [inference]

response to stress [inference]

response to cold

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to cold

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of multicellular organism growth

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

adenylate cyclase-activating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

adrenergic receptor signaling pathway [inference]

adenylate cyclase-activating adrenergic receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

negative regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of G protein-coupled receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth [inference]

negative regulation of multicellular organism growth

positive regulation of multicellular organismal process [inference]

positive regulation of cold-induced thermogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of multicellular organism growth

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of biological quality [inference]

regulation of blood pressure [inference]

negative regulation of blood pressure [inference]

negative regulation of systemic arterial blood pressure [inference]

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation [inference]

norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IBA
receptor complex	IDA	15123695

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
beta-adrenergic receptor activity	IDA	15123695
protein binding	IPI	15123695
beta3-adrenergic receptor activity	IMP	9892244
beta3-adrenergic receptor activity	IBA
beta-3 adrenergic receptor binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

adrenergic receptor binding [inference]

beta-3 adrenergic receptor binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

norepinephrine binding

organic cyclic compound binding [inference]

catecholamine binding [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity [inference]

G protein-coupled amine receptor activity [inference]

adrenergic receptor activity [inference]

beta-adrenergic receptor activity

beta3-adrenergic receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta-3 adrenergic receptor

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
adenylate cyclase-activating adrenergic receptor signaling pathway
adrenergic receptor activity
adrenergic receptor signaling pathway
beta3-adrenergic receptor activity
epinephrine binding
norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure

Displaying **all 2** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources
DOID:0110429	dilated cardiomyopathy 1H	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:13189	gout	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 47 in total

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Species	Gene ID	Orthologous MAtrix
Ovis aries	100294559	SHEEP13161
Callithrix jacchus	100396232	CALJA09033
Pongo abelii	100454445	PONAB34592
Nomascus leucogenys	100596541	NOMLE34998
Loxodonta africana	100674524	LOXAF12228
Cricetulus griseus	100775030	CRIGR04421
Otolemur garnettii	100964485	OTOGA06523
Pan paniscus	100972927	PANPA38052
Gorilla gorilla gorilla	101145102	GORGO40823
Octodon degus	101577061	OCTDE14358

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Acknowledgements