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cytochrome P450 family 3 subfamily A member 4

Summary

Gene Symbol

CYP3A4

Organism

Homo sapiens (human)

External Links

NCBI Gene

1576

HGNC

2637

KEGG Gene ID

hsa:1576

PubChem

1576

Alliance of Genome Resources

HGNC:2637

JoGo

CYP3A4

TogoVar

CYP3A4

Annotation

Keyword

3D-structure
Direct protein sequencing
Disease variant
Fatty acid metabolism
Heme
Microsome
Monooxygenase
Proteomics identification
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol metabolism
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P08684	1,4-cineole 2-exo-monooxygenase 1,8-cineole 2-exo-monooxygenase Albendazole monooxygenase (sulfoxide-forming) Albendazole sulfoxidase CYPIIIA3 CYPIIIA4 Cholesterol 25-hydroxylase Cytochrome P450 3A3 Cytochrome P450 HLp Cytochrome P450 NF-25 Cytochrome P450-PCN1 Nifedipine oxidase Quinine 3-monooxygenase
Q6GRK0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
lipid hydroxylation	IDA
lipid hydroxylation	IEA
lipid metabolic process	TAS
fatty acid metabolic process	IEA
steroid catabolic process	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

xenobiotic metabolic process

xenobiotic catabolic process

catabolic process [inference]

alkaloid catabolic process

lipid catabolic process [inference]

steroid catabolic process

vitamin D catabolic process

xenobiotic catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

alkaloid metabolic process [inference]

alkaloid catabolic process

secondary metabolic process [inference]

toxin metabolic process [inference]

mycotoxin metabolic process [inference]

aflatoxin metabolic process

hormone metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

fatty acid metabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

monoterpenoid metabolic process

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

steroid metabolic process

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

steroid catabolic process

vitamin D catabolic process

sterol metabolic process [inference]

cholesterol metabolic process

vitamin D metabolic process

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin D catabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

steroid biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

lipid catabolic process [inference]

steroid catabolic process

vitamin D catabolic process

lipid modification [inference]

lipid hydroxylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

primary alcohol metabolic process [inference]

retinol metabolic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

secondary alcohol metabolic process [inference]

cholesterol metabolic process

vitamin D3 metabolic process [inference]

calcitriol biosynthetic process from calciol

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

retinoic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

vitamin metabolic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

fat-soluble vitamin catabolic process [inference]

vitamin D catabolic process

small molecule biosynthetic process [inference]

vitamin biosynthetic process [inference]

fat-soluble vitamin biosynthetic process [inference]

vitamin D biosynthetic process [inference]

calcitriol biosynthetic process from calciol

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

calcitriol biosynthetic process from calciol

demethylation [inference]

oxidative demethylation

olefinic compound metabolic process [inference]

retinol metabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IEA
intracellular membrane-bounded organelle	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 44 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	ISS
monooxygenase activity	TAS
monooxygenase activity	IDA
monooxygenase activity	IEA
steroid binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

steroid hydroxylase activity

vitamin D 23-hydroxylase activity [inference]

1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

quinine 3-monooxygenase activity

anandamide epoxidase activity [inference]

1,8-cineole 2-exo-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

retinoic acid 4-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [inference]

quinine 3-monooxygenase activity

anandamide epoxidase activity [inference]

1,8-cineole 2-exo-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on CH or CH2 groups [inference]

oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor [inference]

caffeine oxidase activity

binding [inference]

protein binding

enzyme binding

lipid binding [inference]

steroid binding

small molecule binding [inference]

oxygen binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome p450

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
heme binding
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity

Displaying **all 4** entries
InterPro
Cytochrome P450 superfamily
Cytochrome P450, E-class, group I
Cytochrome P450, conserved site
Cytochrome P450

Human Protein Atlas

ENSG00000160868

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K17689

Name

cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]

References

Rhea

RHEA:55924

O₂ + albendazole

H₂O + H⁺ + albendazole S-oxide

Enzyme

1.14.14.73

PMID

RHEA:20149

quinine + O₂

H₂O + H⁺ + 3-hydroxyquinine

Enzyme

1.14.14.55

PMID

11159812

RHEA:55928

O₂ + fenbendazole

H₂O + H⁺ + fenbendazole S-oxide

Enzyme

1.14.14.73

PMID

RHEA:17149

an organic molecule + O₂

H₂O + H⁺ + an alcohol

Enzyme

1.14.14.1

PMID

RHEA:32895

O₂ + 1,8-cineole

H₂O + H⁺ + 2-exo-hydroxy-1,8-cineole

Enzyme

1.14.14.56

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2987	familial Mediterranean fever	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 14 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000938	Osteopenia
HP:0001510	Growth delay
HP:0002148	Hypophosphatemia
HP:0002901	Hypocalcemia
HP:0002970	Genu varum
HP:0002979	Bowing of the legs
HP:0003015	Flared metaphysis
HP:0003021	Metaphyseal cupping
HP:0003155	Elevated circulating alkaline phosphatase concentration