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cytochrome P450 family 11 subfamily B member 2

Summary

Gene Symbol

CYP11B2

Aliases

ALDOS
CPN2
CYP11BL
P-450C18
P450aldo
steroid 11-beta-monooxygenase

Organism

Homo sapiens (human)

External Links

NCBI Gene

1585

HGNC

2592

KEGG Gene ID

hsa:1585

PubChem

1585

Alliance of Genome Resources

HGNC:2592

JoGo

CYP11B2

TogoVar

CYP11B2

Annotation

Keyword

3D-structure
Disease variant
Heme
Mitochondrion inner membrane
Monooxygenase
Proteomics identification
Reference proteome
Steroid metabolism
Steroidogenesis
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
P19099	Aldosterone synthase Aldosterone-synthesizing enzyme CYPXIB2 Corticosterone 18-monooxygenase, CYP11B2 Cytochrome P-450Aldo Cytochrome P-450C18 Steroid 11-beta-hydroxylase, CYP11B2 Steroid 18-hydroxylase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
regulation of blood volume by renal aldosterone	IMP
renal water homeostasis	IC
C21-steroid hormone biosynthetic process	IDA
glucocorticoid biosynthetic process	IBA
mineralocorticoid biosynthetic process	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process

aldosterone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

mineralocorticoid biosynthetic process

aldosterone biosynthetic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

aldehyde biosynthetic process [inference]

aldosterone biosynthetic process

olefinic compound biosynthetic process [inference]

ketone metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

ketone biosynthetic process [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

mineralocorticoid biosynthetic process

aldosterone biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process

aldosterone biosynthetic process

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

glucocorticoid metabolic process [inference]

glucocorticoid biosynthetic process

cortisol biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

sterol metabolic process

cholesterol metabolic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

glucocorticoid biosynthetic process

cortisol biosynthetic process

mineralocorticoid biosynthetic process

aldosterone biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

primary alcohol biosynthetic process [inference]

cortisol metabolic process

cortisol biosynthetic process

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

tertiary alcohol metabolic process [inference]

cortisol metabolic process

cortisol biosynthetic process

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process

small molecule biosynthetic process [inference]

ketone biosynthetic process [inference]

alcohol biosynthetic process [inference]

primary alcohol biosynthetic process [inference]

tertiary alcohol biosynthetic process [inference]

cortisol biosynthetic process

olefinic compound metabolic process [inference]

aldosterone metabolic process [inference]

aldosterone biosynthetic process

cortisol metabolic process

cortisol biosynthetic process

olefinic compound biosynthetic process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water homeostasis

endocrine process [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of blood volume by renal aldosterone

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

response to chemical [inference]

response to hormone [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

response to metal ion [inference]

response to potassium ion [inference]

cellular response to potassium ion

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus

response to nitrogen compound [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus

response to oxygen-containing compound [inference]

response to peptide hormone [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to hormone stimulus

cellular response to peptide hormone stimulus

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to nitrogen compound [inference]

cellular response to peptide hormone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to peptide hormone stimulus

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal [inference]

regulation of systemic arterial blood pressure by hormone [inference]

regulation of blood volume by renal aldosterone

positive regulation of blood pressure [inference]

positive regulation of systemic arterial blood pressure [inference]

regulation of blood volume by renal aldosterone

regulation of hormone levels [inference]

hormone metabolic process [inference]

C21-steroid hormone metabolic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

mineralocorticoid metabolic process [inference]

mineralocorticoid biosynthetic process

aldosterone biosynthetic process

aldosterone metabolic process [inference]

aldosterone biosynthetic process

hormone biosynthetic process [inference]

C21-steroid hormone biosynthetic process

aldosterone biosynthetic process

mineralocorticoid biosynthetic process

aldosterone biosynthetic process

regulation of body fluid levels [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA
mitochondrion	IEA
mitochondrion	HTP
mitochondrial inner membrane	ISS
mitochondrial inner membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
monooxygenase activity	IEA
steroid 11-beta-monooxygenase activity	TAS
steroid 11-beta-monooxygenase activity	IDA
steroid 11-beta-monooxygenase activity	IBA
steroid 11-beta-monooxygenase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity

steroid hydroxylase activity

steroid 11-beta-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [inference]

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000179142

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07433

Name

steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]

References

Rhea

RHEA:15629

H⁺ + O₂ + a steroid

H₂O + an 11β-hydroxysteroid

Enzyme

1.14.15.4

PMID

RHEA:11872

H⁺ + O₂ + corticosterone

H₂O + 18-hydroxycorticosterone

Enzyme

1.14.15.5

PMID

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:0110429	dilated cardiomyopathy 1H	Alliance of Genome Resources
DOID:9351	diabetes mellitus	Alliance of Genome Resources
DOID:446	primary hyperaldosteronism	Alliance of Genome Resources
DOID:0080626	corticosterone methyloxidase deficiency 1	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:10591	pre-eclampsia	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 34 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000127	Renal salt wasting
HP:0000360	Tinnitus
HP:0000421	Epistaxis
HP:0000811	Abnormal external genitalia
HP:0000822	Hypertension
HP:0000848	Increased circulating renin level
HP:0001278	Orthostatic hypotension
HP:0001290	Generalized hypotonia
HP:0001324	Muscle weakness

Displaying **all 4** entries
Disease ID	Disease Name
ORPHA:403	glucocorticoid-remediable aldosteronism
OMIM:203400	corticosterone methyloxidase type 1 deficiency
OMIM:610600	corticosterone methyloxidase type 2 deficiency
ORPHA:556030	early-onset familial hypoaldosteronism

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001581
Gene Name: cytochrome P450, family 11, subfamily B, polypeptide 2

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements