GlyCosmos Portal

Submissions

insulin-like growth factor binding protein 3

Summary

Gene Symbol

Igfbp3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16009

KEGG Gene ID

PubChem

16009

Alliance of Genome Resources

MGI:96438

Annotation

Keyword

Apoptosis
Disulfide bond
Glycoprotein
Growth factor binding
Phosphoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UR87
P47878

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

1

2

3

4

5

6

Next ›

Last »
GO Term	Evidence Code	PMID
regulation of cell growth	IGI
osteoblast differentiation	IEP
negative regulation of protein phosphorylation	ISO
protein phosphorylation	ISO
apoptotic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cell death [inference]

programmed cell death [inference]

apoptotic process

cell population proliferation [inference]

epithelial cell proliferation [inference]

type B pancreatic cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of testosterone secretion [inference]

negative regulation of testosterone secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of testosterone secretion

regulation of testosterone secretion [inference]

negative regulation of testosterone secretion

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of testosterone secretion [inference]

negative regulation of testosterone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of testosterone secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of testosterone secretion

regulation of testosterone secretion [inference]

negative regulation of testosterone secretion

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of testosterone secretion

regulation of growth

regulation of cell growth

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of testosterone secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of testosterone secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of insulin-like growth factor receptor signaling pathway

positive regulation of insulin-like growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of testosterone secretion [inference]

negative regulation of testosterone secretion

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

regulation of DNA catabolic process [inference]

regulation of apoptotic DNA fragmentation [inference]

positive regulation of apoptotic DNA fragmentation

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of DNA metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

regulation of DNA catabolic process [inference]

regulation of apoptotic DNA fragmentation [inference]

positive regulation of apoptotic DNA fragmentation

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

regulation of DNA catabolic process [inference]

regulation of apoptotic DNA fragmentation [inference]

positive regulation of apoptotic DNA fragmentation

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation

regulation of smooth muscle cell proliferation [inference]

negative regulation of smooth muscle cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of apoptotic process

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

regulation of myoblast differentiation [inference]

positive regulation of myoblast differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA catabolic process [inference]

positive regulation of apoptotic DNA fragmentation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of insulin-like growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of muscle cell apoptotic process [inference]

positive regulation of striated muscle cell apoptotic process [inference]

positive regulation of cardiac muscle cell apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of myoblast differentiation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of smooth muscle cell proliferation

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein phosphorylation

negative regulation of phosphate metabolic process [inference]

negative regulation of phosphorylation [inference]

negative regulation of protein phosphorylation

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cellular component organization [inference]

regulation of cell growth

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of testosterone secretion [inference]

negative regulation of testosterone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of testosterone secretion

regulation of testosterone secretion [inference]

negative regulation of testosterone secretion

Displaying entries **1 - 5** of 14 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
heterochromatin	ISO
extracellular region	ISO
extracellular region	IDA
extracellular region	IBA
extracellular region	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

growth factor complex [inference]

insulin-like growth factor binding protein complex [inference]

extracellular protein-containing complex [inference]

insulin-like growth factor binding protein complex [inference]

cellular anatomical structure [inference]

chromatin [inference]

heterochromatin

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

Displaying entries **1 - 5** of 13 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
fibronectin binding	IDA
fibronectin binding	IBA
fibronectin binding	IEA
insulin-like growth factor binding	IPI
insulin-like growth factor binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

fibronectin binding

growth factor binding [inference]

insulin-like growth factor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

protein phosphatase regulator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity [inference]

protein tyrosine phosphatase activator activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	24484	RGD:2874
Homo sapiens	3486	HGNC:5472

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements