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integrin alpha 4

Summary

Gene Symbol

Itga4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16401

KEGG Gene ID

[""]

PubChem

16401

Alliance of Genome Resources

MGI:96603

Annotation

Keyword

Calcium
Cell adhesion
Disulfide bond
Glycoprotein
Integrin
Metal-binding
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8BQ25
Q792F9	CD49 antigen-like family member D Integrin alpha-IV VLA-4 subunit alpha
Q00651	CD49 antigen-like family member D Integrin alpha-IV Lymphocyte Peyer patch adhesion molecules subunit alpha VLA-4 subunit alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 65 in total

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GO Term	Evidence Code	PMID
blood vessel remodeling	IMP
positive regulation of leukocyte migration	ISO
cell-matrix adhesion involved in ameboidal cell migration	ISO
cell-matrix adhesion involved in ameboidal cell migration	IEA
cell adhesion	IMP

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration

diapedesis

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cellular process [inference]

cell adhesion

cell-substrate adhesion [inference]

cell-matrix adhesion

cell-matrix adhesion involved in ameboidal cell migration

substrate adhesion-dependent cell spreading

cell adhesion mediated by integrin [inference]

cell-cell adhesion mediated by integrin

cell-cell adhesion

heterophilic cell-cell adhesion

leukocyte cell-cell adhesion

leukocyte adhesion to vascular endothelial cell [inference]

leukocyte tethering or rolling

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent extracellular exosome endocytosis

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

cell motility [inference]

cell migration

leukocyte migration

diapedesis

mononuclear cell migration [inference]

lymphocyte migration [inference]

T cell migration

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis [inference]

axonogenesis involved in innervation

anatomical structure development [inference]

tissue development

mesenchyme development

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension

developmental growth involved in morphogenesis [inference]

neuron projection extension

response to stimulus [inference]

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus

response to nitrogen compound [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

response to oxygen-containing compound [inference]

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

response to amyloid-beta [inference]

cellular response to amyloid-beta

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to amyloid-beta

cellular response to oxygen-containing compound [inference]

cellular response to amyloid-beta

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to membrane [inference]

receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent extracellular exosome endocytosis

import into cell

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis [inference]

clathrin-dependent extracellular exosome endocytosis

establishment of localization in cell [inference]

establishment of vesicle localization [inference]

clathrin-dependent extracellular exosome endocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

clathrin-dependent extracellular exosome endocytosis

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

clathrin-dependent extracellular exosome endocytosis

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

clathrin-dependent extracellular exosome endocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte adhesion to vascular endothelial cell [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

regulation of vascular endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

regulation of endothelial cell apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of endothelial cell proliferation [inference]

positive regulation of vascular endothelial cell proliferation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of endothelial cell apoptotic process

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of lymphocyte migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of T cell migration [inference]

positive regulation of T cell migration

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration

positive regulation of mononuclear cell migration [inference]

positive regulation of lymphocyte migration [inference]

positive regulation of T cell migration

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

negative regulation of multicellular organismal process [inference]

negative regulation of vasoconstriction

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

regulation of vasoconstriction [inference]

negative regulation of vasoconstriction

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IEA
cell-cell junction	IDA
integrin complex	IEA
external side of plasma membrane	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

site of polarized growth [inference]

growth cone

cell body [inference]

neuronal cell body

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
fibronectin binding	ISO
fibronectin binding	IMP
fibronectin binding	IEA
antigen binding	ISO
protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

antigen binding

protein antigen binding

protein binding

fibronectin binding

cytokine binding [inference]

chemokine binding [inference]

C-X3-C chemokine binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

integrin alpha

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
cell adhesion mediated by integrin
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

Displaying **all 9** entries
InterPro
FG-GAP repeat
Integrin alpha beta-propellor
Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Integrin alpha chain
Integrin alpha, N-terminal
Integrin alpha, first immunoglubulin-like domain
Integrin alpha, second immunoglobulin-like domain
Integrin alpha, third immunoglobulin-like domain
Integrin domain superfamily

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements