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Guidelines

MIRAGE

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Summary

Gene Symbol

Lrp8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

16975

KEGG Gene ID

PubChem

16975

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Disulfide bond
EGF-like domain
Endocytosis
Glycoprotein
Metal-binding
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 5** entries
UniProt	Protein Name
B1AXJ4	Apolipoprotein E receptor 2
Q924X6	Apolipoprotein E receptor 2
B1AXJ5	Apolipoprotein E receptor 2
F6YZZ8
A0A571BE60

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
endocytosis	ISS
endocytosis	ISO
endocytosis	IEA
chemical synaptic transmission	IMP
nervous system development	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

cell surface receptor signaling pathway [inference]

reelin-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure formation involved in morphogenesis [inference]

layer formation in cerebral cortex

anatomical structure development [inference]

system development [inference]

nervous system development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

response to chemical [inference]

response to xenobiotic stimulus

response to lipid [inference]

response to sterol [inference]

cellular response to sterol [inference]

cellular response to cholesterol

response to cholesterol [inference]

cellular response to cholesterol

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

response to oxygen-containing compound [inference]

response to sterol [inference]

cellular response to sterol [inference]

cellular response to cholesterol

response to cholesterol [inference]

cellular response to cholesterol

response to alcohol [inference]

response to cholesterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to oxygen-containing compound [inference]

cellular response to sterol [inference]

cellular response to cholesterol

cellular response to alcohol [inference]

cellular response to cholesterol

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response [inference]

regulation of innate immune response

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendritic spine development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendrite development

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response

regulation of response to external stimulus [inference]

regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendritic spine morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendrite development

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendritic spine development [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendrite development

regulation of dendritic spine development [inference]

positive regulation of dendritic spine development [inference]

positive regulation of dendritic spine morphogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

reelin-mediated signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of dendrite development

regulation of dendritic spine morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis [inference]

positive regulation of dendritic spine morphogenesis

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
extracellular region	IDA
extracellular region	IEA
obsolete extracellular space
microtubule associated complex	ISO
plasma membrane	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	IPI
low-density lipoprotein particle receptor activity	TAS
low-density lipoprotein particle receptor activity	IEA
calcium ion binding	IEA
protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

kinesin binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

high-density lipoprotein particle binding

cargo receptor activity [inference]

lipoprotein particle receptor activity [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

reelin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

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Last updated: April 6, 2026