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MIRAGE

beta-carotene oxygenase 2

Summary

Gene Symbol

Bco2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

170752

KEGG Gene ID

PubChem

170752

Alliance of Genome Resources

MGI:2177469

Annotation

Keyword

Dioxygenase
Iron
Lipid metabolism
Metal-binding
Mitochondrion
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q99NF1	B-diox-II Beta,beta-carotene 9',10'-oxygenase Beta-carotene dioxygenase 2
Q3KNZ2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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2

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GO Term	Evidence Code	PMID
isoprenoid metabolic process	IEA
carotenoid metabolic process	IMP
carotene metabolic process	ISO
carotene metabolic process	IDA
carotene metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

retinal metabolic process

catabolic process [inference]

lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

hydrocarbon catabolic process [inference]

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

hormone metabolic process [inference]

retinoic acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

isoprenoid metabolic process

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

carotenoid metabolic process

carotenoid catabolic process [inference]

xanthophyll catabolic process

xanthophyll metabolic process

xanthophyll catabolic process

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

terpene metabolic process [inference]

carotene metabolic process

carotene catabolic process

lycopene catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

hydrocarbon metabolic process [inference]

terpene metabolic process [inference]

carotene metabolic process

carotene catabolic process

lycopene catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

hydrocarbon catabolic process [inference]

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

olefinic compound metabolic process [inference]

retinal metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of reactive oxygen species metabolic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinoic acid metabolic process

regulation of membrane potential [inference]

regulation of mitochondrial membrane potential

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
beta-carotene 15,15'-dioxygenase activity	IBA
carotenoid dioxygenase activity	IBA
9,10 (9', 10')-carotenoid-cleaving dioxygenase activity	ISS
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ISO
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

beta-carotene 15,15'-dioxygenase activity

carotenoid dioxygenase activity

9,10 (9', 10')-carotenoid-cleaving dioxygenase activity

beta,beta-carotene-9',10'-cleaving oxygenase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

beta-carotene 15,15'-dioxygenase activity

carotenoid dioxygenase activity

9,10 (9', 10')-carotenoid-cleaving dioxygenase activity

beta,beta-carotene-9',10'-cleaving oxygenase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta,beta-carotene 9',10'-oxygenase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
beta-carotene 15,15'-dioxygenase activity
carotene catabolic process
carotenoid dioxygenase activity
metal ion binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
retinal metabolic process

Displaying 1 entry
InterPro
Carotenoid oxygenase

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	83875	HGNC:18503

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026