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dyskerin pseudouridine synthase 1

Summary

Gene Symbol

Dkc1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

170944

KEGG Gene ID

[""]

PubChem

170944

Alliance of Genome Resources

RGD:621780

Annotation

Keyword

Acetylation
Direct protein sequencing
Isomerase
Isopeptide bond
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Ribonucleoprotein
Ribosome biogenesis
Ubl conjugation
rRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
P40615	Dyskerin Nopp140-associated protein of 57 kDa Nucleolar protein NAP57 Nucleolar protein family A member 4 snoRNP protein DKC1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
snoRNA guided rRNA pseudouridine synthesis	IDA
enzyme-directed rRNA pseudouridine synthesis	ISS
enzyme-directed rRNA pseudouridine synthesis	ISO
box H/ACA sno(s)RNA 3'-end processing	IBA
pseudouridine synthesis	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

macromolecule modification [inference]

RNA modification

rRNA modification [inference]

rRNA pseudouridine synthesis

pseudouridine synthesis

rRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

snRNA modification [inference]

snRNA pseudouridine synthesis

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

RNA metabolic process [inference]

RNA modification

rRNA modification [inference]

rRNA pseudouridine synthesis

pseudouridine synthesis

rRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

snRNA modification [inference]

snRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA modification [inference]

mRNA pseudouridine synthesis

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA pseudouridine synthesis

snRNA metabolic process [inference]

snRNA processing [inference]

snRNA modification [inference]

snRNA pseudouridine synthesis

sno(s)RNA metabolic process [inference]

box H/ACA sno(s)RNA metabolic process

box H/ACA sno(s)RNA processing [inference]

box H/ACA sno(s)RNA 3'-end processing

sno(s)RNA processing [inference]

sno(s)RNA 3'-end processing [inference]

box H/ACA sno(s)RNA 3'-end processing

box H/ACA sno(s)RNA processing [inference]

box H/ACA sno(s)RNA 3'-end processing

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

RNA metabolic process [inference]

RNA modification

rRNA modification [inference]

rRNA pseudouridine synthesis

pseudouridine synthesis

rRNA pseudouridine synthesis

mRNA modification [inference]

mRNA pseudouridine synthesis

snRNA modification [inference]

snRNA pseudouridine synthesis

mRNA metabolic process [inference]

mRNA modification [inference]

mRNA pseudouridine synthesis

rRNA metabolic process [inference]

rRNA processing [inference]

rRNA modification [inference]

rRNA pseudouridine synthesis

snRNA metabolic process [inference]

snRNA processing [inference]

snRNA modification [inference]

snRNA pseudouridine synthesis

sno(s)RNA metabolic process [inference]

box H/ACA sno(s)RNA metabolic process

box H/ACA sno(s)RNA processing [inference]

box H/ACA sno(s)RNA 3'-end processing

sno(s)RNA processing [inference]

sno(s)RNA 3'-end processing [inference]

box H/ACA sno(s)RNA 3'-end processing

box H/ACA sno(s)RNA processing [inference]

box H/ACA sno(s)RNA 3'-end processing

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

RNA processing

rRNA processing [inference]

rRNA modification [inference]

rRNA pseudouridine synthesis

snRNA processing [inference]

snRNA modification [inference]

snRNA pseudouridine synthesis

RNA 3'-end processing [inference]

sno(s)RNA 3'-end processing [inference]

box H/ACA sno(s)RNA 3'-end processing

sno(s)RNA processing [inference]

sno(s)RNA 3'-end processing [inference]

box H/ACA sno(s)RNA 3'-end processing

box H/ACA sno(s)RNA processing [inference]

box H/ACA sno(s)RNA 3'-end processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

telomerase holoenzyme complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

telomerase holoenzyme complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

telomerase holoenzyme complex assembly

localization [inference]

macromolecule localization [inference]

RNA localization [inference]

RNA localization to nucleus [inference]

RNA localization to Cajal body [inference]

scaRNA localization to Cajal body

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of telomerase RNA localization to Cajal body

positive regulation of telomerase RNA localization to Cajal body

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of telomerase RNA localization to Cajal body

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

RNA stabilization [inference]

telomerase RNA stabilization

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

regulation of DNA biosynthetic process [inference]

regulation of telomere maintenance via telomerase [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

regulation of RNA stability [inference]

RNA stabilization [inference]

telomerase RNA stabilization

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

RNA stabilization [inference]

telomerase RNA stabilization

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

regulation of DNA biosynthetic process [inference]

regulation of telomere maintenance via telomerase [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

regulation of telomere maintenance via telomere lengthening [inference]

regulation of telomere maintenance via telomerase [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

regulation of DNA biosynthetic process [inference]

regulation of telomere maintenance via telomerase [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

RNA stabilization [inference]

telomerase RNA stabilization

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

regulation of DNA metabolic process [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

regulation of telomere maintenance via telomere lengthening [inference]

regulation of telomere maintenance via telomerase [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

regulation of DNA biosynthetic process [inference]

regulation of telomere maintenance via telomerase [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

RNA stabilization [inference]

telomerase RNA stabilization

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA metabolic process [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of DNA biosynthetic process [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

negative regulation of macromolecule metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

telomerase RNA stabilization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

regulation of chromosome organization [inference]

regulation of telomere maintenance [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

regulation of telomere maintenance via telomere lengthening [inference]

regulation of telomere maintenance via telomerase [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of telomere maintenance [inference]

positive regulation of telomere maintenance via telomere lengthening [inference]

positive regulation of telomere maintenance via telomerase

regulation of biological quality [inference]

regulation of RNA stability [inference]

RNA stabilization [inference]

telomerase RNA stabilization

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
fibrillar center	ISO
nucleus	ISO
nucleoplasm	ISO
nucleoplasm	IDA
telomerase holoenzyme complex	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

catalytic complex [inference]

ribonucleoprotein complex [inference]

telomerase holoenzyme complex

sno(s)RNA-containing ribonucleoprotein complex [inference]

box H/ACA RNP complex [inference]

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

supramolecular complex [inference]

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
telomerase activity	ISO
RNA binding	ISO
RNA binding	IEA
protein binding	IPI
pseudouridine synthase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

RNA-directed DNA polymerase activity [inference]

telomerase activity

isomerase activity [inference]

intramolecular transferase activity [inference]

pseudouridine synthase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity [inference]

RNA-directed DNA polymerase activity [inference]

telomerase activity

binding [inference]

nucleic acid binding [inference]

RNA binding

snoRNA binding [inference]

box H/ACA snoRNA binding

telomerase RNA binding

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

H/ACA ribonucleoprotein complex subunit

Functional Category

E: Amino acid transport and metabolism
H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 5** entries
Gene Ontology
box H/ACA RNA 3'-end processing
mRNA pseudouridine synthesis
pseudouridine synthesis
rRNA pseudouridine synthesis
snRNA pseudouridine synthesis

Displaying **all 9** entries
InterPro
Dyskerin-like
PUA domain superfamily
PUA domain
PUA-like superfamily
Pseudouridine synthase II, N-terminal
Pseudouridine synthase, catalytic domain superfamily
Uncharacterised domain CHP00451
tRNA pseudouridine synthase B family
tRNA pseudouridylate synthase B, C-terminal

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
nucleoplasm	PMID:7798307
box H/ACA snoRNP complex	PMID:10679015 PMID:12446766
Cajal body	PMID:7798307

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements