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Guidelines

MIRAGE

spondin 2

Summary

Gene Symbol

Spon2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

171569

PubChem

171569

Alliance of Genome Resources

RGD:708584

Annotation

Keyword

Calcium
Cell adhesion
Disulfide bond
Extracellular matrix
Glycoprotein
Innate immunity
Metal-binding
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6IK68	Mindin
Q9WV75	Mindin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

1

2

3

4

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Last »
GO Term	Evidence Code	PMID
mast cell mediated immunity	ISO
cell adhesion	IDA
cell adhesion	IBA
opsonization	ISO
response to lipopolysaccharide	ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

myeloid leukocyte mediated immunity [inference]

mast cell mediated immunity

opsonization

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

cellular process [inference]

cell adhesion

cell population proliferation [inference]

muscle cell proliferation [inference]

smooth muscle cell proliferation [inference]

vascular associated smooth muscle cell proliferation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium

antibacterial humoral response [inference]

induction of bacterial agglutination

response to fungus [inference]

defense response to fungus

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium

antibacterial humoral response [inference]

induction of bacterial agglutination

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium

antibacterial humoral response [inference]

induction of bacterial agglutination

response to fungus [inference]

defense response to fungus

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to other organism [inference]

response to virus [inference]

defense response to virus

response to bacterium [inference]

defense response to bacterium

antibacterial humoral response [inference]

induction of bacterial agglutination

response to fungus [inference]

defense response to fungus

defense response to other organism [inference]

defense response to symbiont [inference]

antimicrobial humoral response [inference]

antibacterial humoral response [inference]

induction of bacterial agglutination

innate immune response

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to endogenous stimulus [inference]

response to growth factor [inference]

response to platelet-derived growth factor [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of interleukin-6 production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	IEA
obsolete extracellular space
extracellular matrix	ISO
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

Displaying entries **1 - 5** of 6 in total

1

2

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Last »
GO Term	Evidence Code	PMID
lipopolysaccharide binding	ISO
lipopolysaccharide binding	IEA
antigen binding	ISO
antigen binding	IEA
signaling receptor binding	IDA

GO Hierarchy

molecular function

binding [inference]

antigen binding

protein binding [inference]

signaling receptor binding

lipid binding [inference]

lipopolysaccharide binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Spondin

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 5** entries
InterPro
Spondin, N-terminal domain superfamily
Spondin, N-terminal
Spondin-like TSP1 domain
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026