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Guidelines

MIRAGE

Netrin receptor unc-40

Summary

Gene Symbol

unc-40

Organism

Caenorhabditis elegans

External Links

NCBI Gene

172233

KEGG Gene ID

PubChem

172233

Alliance of Genome Resources

WB:WBGene00006776

Annotation

Keyword

Cell membrane
Disulfide bond
Immunoglobulin domain
Neurogenesis
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
G5EF96	Uncoordinated protein 40

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
neuron migration	IMP
neuron migration	IBA
axon guidance	IBA
motor neuron axon guidance	IMP
motor neuron axon guidance	IGI

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

cell recognition [inference]

neuron recognition [inference]

axon choice point recognition [inference]

axon midline choice point recognition

cell motility [inference]

cell migration [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

reproductive process [inference]

developmental process involved in reproduction [inference]

gonad morphogenesis

multicellular organismal process [inference]

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry [inference]

determination of left/right asymmetry in nervous system

developmental process [inference]

developmental process involved in reproduction [inference]

gonad morphogenesis

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

gonad morphogenesis

cell projection morphogenesis

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

male anatomical structure morphogenesis [inference]

nematode male tail tip morphogenesis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

chemorepulsion of axon

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

regulation of multicellular organism growth [inference]

positive regulation of multicellular organism growth

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of axon guidance [inference]

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of sensory neuron axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of cell motility [inference]

regulation of cell migration

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

positive regulation of multicellular organismal process [inference]

positive regulation of multicellular organism growth

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of axon guidance [inference]

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of sensory neuron axon guidance [inference]

negative regulation of sensory neuron axon guidance

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of cellular response to growth factor stimulus [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of developmental process [inference]

regulation of cell fate commitment [inference]

regulation of cell fate specification [inference]

regulation of mesodermal cell fate specification

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of animal organ morphogenesis [inference]

regulation of mesodermal cell fate specification

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of mesodermal cell differentiation [inference]

regulation of mesodermal cell fate specification

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

regulation of multicellular organism growth [inference]

positive regulation of multicellular organism growth

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of multicellular organism growth

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

regulation of cell fate commitment [inference]

regulation of cell fate specification [inference]

regulation of mesodermal cell fate specification

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of BMP signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of mesodermal cell differentiation [inference]

regulation of mesodermal cell fate specification

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of BMP signaling pathway

positive regulation of cellular component biogenesis [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon guidance [inference]

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of sensory neuron axon guidance [inference]

negative regulation of sensory neuron axon guidance

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of axon guidance [inference]

negative regulation of sensory neuron axon guidance

positive regulation of cellular component organization [inference]

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

positive regulation of synapse assembly

positive regulation of cell junction assembly [inference]

positive regulation of synapse assembly

regulation of cell motility [inference]

regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of multicellular organism growth [inference]

positive regulation of multicellular organism growth

positive regulation of multicellular organismal process [inference]

positive regulation of multicellular organism growth

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

positive regulation of nervous system development [inference]

positive regulation of synapse assembly

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA
membrane	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane

site of polarized growth [inference]

growth cone [inference]

axonal growth cone

Displaying **all 4** entries
GO Term	Evidence Code	PMID
netrin receptor activity	ISS
netrin receptor activity	IMP
protein binding	IPI
protein domain specific binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

netrin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Neogenin

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Neogenin, C-terminal

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
membrane	PMID:23539368
cytoplasm	PMID:8861903
synapse	PMID:32471987
plasma membrane	PMID:16520734 PMID:19211675 PMID:19686680 PMID:31488562
cell projection	PMID:19211675
cell leading edge	PMID:31488562
cell periphery	PMID:31488562

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13176	MGI:94869
Mus musculus	18007	MGI:1097159
Rattus norvegicus	25311	RGD:2492
Homo sapiens	1630	HGNC:2701
Homo sapiens	4756	HGNC:7754

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Last updated: April 6, 2026