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dihydrolipoamide S-succinyltransferase

Summary

Gene Symbol

DLST

Aliases

2-oxoglutarate dehydrogenase complex component E2
Dihydrolipoyllysine-residue succinyltransferase
KGD2
OGDC-E2

Organism

Homo sapiens (human)

External Links

NCBI Gene

1743

HGNC

2911

KEGG Gene ID

hsa:1743

PubChem

1743

Alliance of Genome Resources

HGNC:2911

JoGo

DLST

TogoVar

DLST

Annotation

Keyword

3D-structure
Acetylation
Acyltransferase
Alternative splicing
Direct protein sequencing
Disease variant
Lipoyl
Mitochondrion
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transferase
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7Z6J1
P36957	2-oxoglutarate dehydrogenase complex component E2 Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex E2K

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
generation of precursor metabolites and energy	TAS
tricarboxylic acid cycle	NAS
tricarboxylic acid cycle	IMP
tricarboxylic acid cycle	IBA
tricarboxylic acid cycle	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy

sulfur compound metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

sulfur compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

primary metabolic process [inference]

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

2-oxoglutarate metabolic process

2-oxoglutarate decarboxylation to succinyl-CoA

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

nucleoside phosphate biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound metabolic process [inference]

acyl-CoA metabolic process [inference]

succinyl-CoA metabolic process

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

purine-containing compound biosynthetic process [inference]

acyl-CoA biosynthetic process [inference]

succinyl-CoA biosynthetic process [inference]

2-oxoglutarate decarboxylation to succinyl-CoA

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
nucleus	IDA
nucleus	IEA
nucleus	HDA
nucleoplasm	IDA
mitochondrion	NAS

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle heteromeric enzyme complex [inference]

oxoglutarate dehydrogenase complex

oxidoreductase complex [inference]

alpha-ketoacid dehydrogenase complex [inference]

transferase complex [inference]

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
dihydrolipoyllysine-residue succinyltransferase activity	ISS
dihydrolipoyllysine-residue succinyltransferase activity	IMP
dihydrolipoyllysine-residue succinyltransferase activity	IBA
dihydrolipoyllysine-residue succinyltransferase activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

S-acyltransferase activity [inference]

S-succinyltransferase activity [inference]

dihydrolipoyllysine-residue succinyltransferase activity

dihydrolipoyllysine-residue glutaryltransferase activity

succinyltransferase activity [inference]

S-succinyltransferase activity [inference]

dihydrolipoyllysine-residue succinyltransferase activity

catalytic activity, acting on a protein [inference]

dihydrolipoyllysine-residue succinyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
L-lysine catabolic process to acetyl-CoA via saccharopine
dihydrolipoyllysine-residue succinyltransferase activity
tricarboxylic acid cycle

Displaying **all 6** entries
InterPro
2-oxo acid dehydrogenase, lipoyl-binding site
2-oxoacid dehydrogenase acyltransferase, catalytic domain
Biotin/lipoyl attachment
Chloramphenicol acetyltransferase-like domain superfamily
Dihydrolipoamide succinyltransferase
Single hybrid motif

Human Protein Atlas

ENSG00000119689

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00658

Name

2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) [EC:2.3.1.61]

References

Rhea

RHEA:15213

succinyl-CoA

CoA

Enzyme

2.3.1.61

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050773	paraganglioma	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 43 in total

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000093	Proteinuria
HP:0000096	Glomerular sclerosis
HP:0000405	Conductive hearing impairment
HP:0000526	Aniridia
HP:0000740	Episodic paroxysmal anxiety
HP:0000790	Hematuria
HP:0000980	Pallor
HP:0001069	Episodic hyperhidrosis
HP:0001095	Hypertensive retinopathy