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Guidelines

MIRAGE

malate dehydrogenase 2, NAD (mitochondrial)

Summary

Gene Symbol

Mdh2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

17448

KEGG Gene ID

PubChem

17448

Alliance of Genome Resources

MGI:97050

Annotation

Keyword

Acetylation
Direct protein sequencing
Glycoprotein
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
P08249

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
gluconeogenesis	IDA
tricarboxylic acid cycle	ISO
tricarboxylic acid cycle	IDA
tricarboxylic acid cycle	IBA
tricarboxylic acid cycle	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process

dicarboxylic acid metabolic process [inference]

malate metabolic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

malate-aspartate shuttle

carbohydrate derivative metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
mitochondrion	ISA
mitochondrion	ISO
mitochondrion	IBA
mitochondrion	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

myelin sheath

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
RNA binding	ISS
RNA binding	IEA
catalytic activity	IEA
oxidoreductase activity	IEA
malate dehydrogenase activity	ISA

GO Hierarchy

molecular function

catalytic activity

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding [inference]

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

malate dehydrogenase

Functional Category

C: Energy production and conversion
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
L-malate dehydrogenase activity
carboxylic acid metabolic process
catalytic activity
malate dehydrogenase activity
malate metabolic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity
tricarboxylic acid cycle

Displaying **all 7** entries
InterPro
L-lactate/malate dehydrogenase
Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Lactate/malate dehydrogenase, C-terminal
Lactate/malate dehydrogenase, N-terminal
Malate dehydrogenase, active site
Malate dehydrogenase, type 1
NAD(P)-binding domain superfamily

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	81829	RGD:619719
Homo sapiens	4191	HGNC:6971
Saccharomyces cerevisiae S288C	851481	SGD:S000002236
Saccharomyces cerevisiae S288C	853994	SGD:S000005486
Saccharomyces cerevisiae S288C	853777	SGD:S000001568

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026