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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

Matrix metalloproteinase-B

Summary

Gene Symbol

zmp-2

Organism

Caenorhabditis elegans

External Links

NCBI Gene

175383

KEGG Gene ID

PubChem

175383

Alliance of Genome Resources

WB:WBGene00019212

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
larval development	IMP
proteolysis	IEA
determination of adult lifespan	IMP
determination of adult lifespan	IGI
heat acclimation	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

collagen catabolic process

collagen metabolic process [inference]

collagen catabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

multicellular organismal process [inference]

multicellular organism development [inference]

larval development

determination of adult lifespan

post-embryonic development [inference]

larval development

molting cycle process [inference]

ecdysis, collagen and cuticulin-based cuticle

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

larval development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to heat [inference]

heat acclimation

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-negative bacterium

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

heat acclimation

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization to nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization to nucleus [inference]

negative regulation of protein import into nucleus

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol import [inference]

positive regulation of cholesterol import

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of cholesterol import [inference]

positive regulation of cholesterol import

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

regulation of locomotion [inference]

positive regulation of locomotion

positive regulation of biological process [inference]

positive regulation of locomotion

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular response to heat

positive regulation of response to stimulus [inference]

positive regulation of cellular response to heat

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol import

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

negative regulation of protein localization to nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of establishment of protein localization [inference]

negative regulation of protein transport [inference]

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of cellular response to heat

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to heat [inference]

positive regulation of cellular response to heat

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of reactive oxygen species biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of protein oxidation [inference]

negative regulation of protein oxidation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of protein oxidation [inference]

negative regulation of protein oxidation

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

regulation of reactive oxygen species metabolic process [inference]

regulation of reactive oxygen species biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular response to heat

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein oxidation

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

negative regulation of intracellular transport [inference]

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of intracellular protein transport [inference]

negative regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus [inference]

negative regulation of protein import into nucleus

negative regulation of nucleocytoplasmic transport [inference]

negative regulation of protein import into nucleus

regulation of cellular response to stress [inference]

regulation of cellular response to heat [inference]

positive regulation of cellular response to heat

regulation of multicellular organismal process [inference]

regulation of behavior [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

regulation of feeding behavior [inference]

regulation of eating behavior [inference]

positive regulation of eating behavior

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

positive regulation of multicellular organismal process [inference]

positive regulation of behavior [inference]

positive regulation of feeding behavior [inference]

positive regulation of eating behavior

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IBA
obsolete extracellular space
extracellular matrix	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

external encapsulating structure [inference]

extracellular matrix

Displaying **all 5** entries
GO Term	Evidence Code	PMID
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA
metallopeptidase activity	IMP
metallopeptidase activity	IEA
zinc ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Matrix metalloproteinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
collagen catabolic process
extracellular matrix organization
hydrolase activity
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis
zinc ion binding

Displaying **all 7** entries
InterPro
Metallopeptidase, catalytic domain superfamily
PGBD-like superfamily
Peptidase M10, metallopeptidase
Peptidase M10A, catalytic domain
Peptidase M10A
Peptidase, metallopeptidase
Peptidoglycan binding-like

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	81686	RGD:621316
Rattus norvegicus	81687	RGD:621320
Homo sapiens	8510	HGNC:7171

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Last updated: April 6, 2026