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dynamin 2

Summary

Gene Symbol

DNM2

Aliases

CMT2M
CMTDI1
CMTDIB
DI-CMTB
DYN2
DYNII
cytoskeletal protein
dynamin II

Organism

Homo sapiens (human)

External Links

NCBI Gene

1785

HGNC

2974

KEGG Gene ID

PubChem

1785

Alliance of Genome Resources

HGNC:2974

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell junction
Cell projection
Charcot-Marie-Tooth disease
Coated pit
Cytoplasmic vesicle
Cytoskeleton
Disease variant
Endocytosis
Endosome
GTP-binding
Hydrolase
Microtubule
Motor protein
Neurodegeneration
Phagocytosis
Phosphoprotein
Proteomics identification
Reference proteome
Synaptosome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P50570	Dynamin 2 Dynamin II
Q8N1K8

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
G2/M transition of mitotic cell cycle	NAS
regulation of transcription, DNA-templated	NAS
regulation of DNA-templated transcription	NAS
post-Golgi vesicle-mediated transport	TAS
endocytosis	NAS

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

cellular process [inference]

microtubule-based process [inference]

microtubule organizing center organization [inference]

centrosome cycle

signal transduction

metabolic process [inference]

catabolic process [inference]

autophagy

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

receptor internalization

phagocytosis

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport

cell cycle process [inference]

centrosome cycle

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

stress fiber assembly

synaptic vesicle transport

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

stress fiber assembly

vesicle organization [inference]

vesicle budding from membrane [inference]

synaptic vesicle budding [inference]

synaptic vesicle budding from presynaptic endocytic zone membrane

cellular component assembly [inference]

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

protein-containing complex assembly [inference]

protein polymerization

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

microtubule organizing center organization [inference]

centrosome cycle

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization

membrane organization

vesicle budding from membrane [inference]

synaptic vesicle budding [inference]

synaptic vesicle budding from presynaptic endocytic zone membrane

membrane fission [inference]

vesicle scission

membrane tubulation

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

transferrin transport

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport [inference]

transferrin transport

protein transport [inference]

transferrin transport

vesicle-mediated transport [inference]

endocytosis

receptor-mediated endocytosis

receptor internalization

phagocytosis

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport

synaptic vesicle transport

import into cell [inference]

endocytosis

receptor-mediated endocytosis

receptor internalization

phagocytosis

establishment of protein localization [inference]

protein transport [inference]

transferrin transport

establishment of localization in cell [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

synaptic vesicle localization [inference]

synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of membrane tubulation

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of axon extension

regulation of cellular process [inference]

signal transduction

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of membrane tubulation

regulation of cellular component organization [inference]

regulation of cell growth [inference]

regulation of extent of cell growth [inference]

regulation of axon extension

negative regulation of cellular component organization [inference]

negative regulation of membrane tubulation

regulation of plasma membrane organization [inference]

regulation of membrane tubulation [inference]

negative regulation of membrane tubulation

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
phagocytic cup	IEA
uropod	IDA
uropod	IEA
podosome	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

microtubule organizing center [inference]

centrosome

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane

phagocytic vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

endocytic vesicle membrane

phagocytic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

anchoring junction

cell-substrate junction [inference]

focal adhesion

site of polarized growth [inference]

growth cone

midbody

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

podosome

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

recycling endosome

coated vesicle [inference]

clathrin-coated vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

recycling endosome

coated vesicle [inference]

clathrin-coated vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

recycling endosome

coated vesicle [inference]

clathrin-coated vesicle

intracellular membraneless organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynaptic specialization [inference]

postsynaptic density

presynapse

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

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GO Term	Evidence Code	PMID
GTPase activity	NAS
GTPase activity	TAS
GTPase activity	IDA
GTPase activity	IBA
GTPase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding [inference]

microtubule binding

enzyme binding

protein domain specific binding [inference]

SH3 domain binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000079805

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:19669

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060558	lethal congenital contracture syndrome	Alliance of Genome Resources
DOID:0110197	Charcot-Marie-Tooth disease dominant intermediate B	Alliance of Genome Resources
DOID:0111223	centronuclear myopathy 1	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000020	Urinary incontinence
HP:0000028	Cryptorchidism
HP:0000508	Ptosis
HP:0000544	External ophthalmoplegia
HP:0000573	Retinal hemorrhage
HP:0000762	Decreased nerve conduction velocity
HP:0000764	Peripheral axonal degeneration
HP:0000883	Thin ribs

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:160150	autosomal dominant centronuclear myopathy
OMIM:615368	fetal akinesia-cerebral and retinal hemorrhage syndrome
OMIM:606482	Charcot-Marie-Tooth disease dominant intermediate B
ORPHA:169189	autosomal dominant centronuclear myopathy

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	13430	MGI:109547
Saccharomyces cerevisiae S288C	853870	SGD:S000001709

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

PubChem Disease

International Collaboration

Acknowledgements