GlyCosmos Portal

Annotation

Keyword

Acetylation
Aminotransferase
Direct protein sequencing
Disease variant
Disulfide bond
Iron-sulfur
Mitochondrion
Neurotransmitter degradation
Proteomics identification
Pyridoxal phosphate
Reference proteome
Transit peptide

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P80404	(S)-3-amino-2-methylpropionate transaminase GABA aminotransferase Gamma-amino-N-butyrate transaminase L-AIBAT
H3BNQ7	(S)-3-amino-2-methylpropionate transaminase GABA aminotransferase Gamma-amino-N-butyrate transaminase L-AIBAT
X5D8S1	(S)-3-amino-2-methylpropionate transaminase GABA aminotransferase Gamma-amino-N-butyrate transaminase L-AIBAT

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEA
copulation	IEA
locomotory behavior	IEA
response to xenobiotic stimulus	IEA
GABA metabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

amino acid catabolic process [inference]

GABA catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

non-proteinogenic amino acid catabolic process [inference]

GABA catabolic process

biosynthetic process [inference]

amino acid biosynthetic process [inference]

GABA biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

GABA biosynthetic process

amino acid catabolic process [inference]

GABA catabolic process

non-proteinogenic amino acid metabolic process [inference]

GABA metabolic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid catabolic process [inference]

GABA catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

non-proteinogenic amino acid catabolic process [inference]

GABA catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

GABA metabolic process

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

carboxylic acid catabolic process [inference]

non-proteinogenic amino acid catabolic process [inference]

GABA catabolic process

non-proteinogenic amino acid metabolic process [inference]

GABA metabolic process

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

non-proteinogenic amino acid catabolic process [inference]

GABA catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

non-proteinogenic amino acid catabolic process [inference]

GABA catabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

non-proteinogenic amino acid biosynthetic process [inference]

GABA biosynthetic process

reproductive process [inference]

multicellular organismal reproductive process [inference]

reproductive behavior [inference]

mating behavior [inference]

copulation

multicellular organismal process [inference]

system process [inference]

nervous system process

behavior [inference]

locomotory behavior

reproductive behavior [inference]

mating behavior [inference]

copulation

exploration behavior

developmental process [inference]

anatomical structure development [inference]

cerebellum development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to xenobiotic stimulus

response to metal ion [inference]

response to iron ion

response to nicotine

response to nitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to oxygen-containing compound [inference]

response to cocaine

response to alcohol [inference]

response to ethanol

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of organic acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

positive regulation of organic acid transport [inference]

positive regulation of aspartate secretion

regulation of aspartate secretion [inference]

positive regulation of aspartate secretion

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of aspartate secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of aspartate secretion

regulation of aspartate secretion [inference]

positive regulation of aspartate secretion

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of aspartate secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of aspartate secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

regulation of amine transport [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

regulation of amino acid transport [inference]

regulation of gamma-aminobutyric acid secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

regulation of aspartate secretion [inference]

positive regulation of aspartate secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of amine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of aspartate secretion

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of aspartate secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of aspartate secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of inhibitory postsynaptic potential

positive regulation of heat generation

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction [inference]

positive regulation of uterine smooth muscle contraction

positive regulation of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of transport [inference]

negative regulation of organic acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion [inference]

negative regulation of gamma-aminobutyric acid secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amine transport [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of amino acid transport [inference]

negative regulation of gamma-aminobutyric acid secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of amine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of amine metabolic process [inference]

positive regulation of amine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

positive regulation of dopamine metabolic process

regulation of primary metabolic process [inference]

regulation of catecholamine metabolic process [inference]

regulation of dopamine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of amine metabolic process [inference]

positive regulation of dopamine metabolic process

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of aspartate secretion

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

regulation of catecholamine secretion [inference]

regulation of dopamine secretion [inference]

negative regulation of dopamine secretion

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

negative regulation of secretion by cell [inference]

negative regulation of catecholamine secretion [inference]

negative regulation of dopamine secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of aspartate secretion

regulation of aspartate secretion [inference]

positive regulation of aspartate secretion

regulation of multicellular organismal process [inference]

regulation of heat generation [inference]

positive regulation of heat generation

regulation of system process [inference]

regulation of nervous system process [inference]

positive regulation of nervous system process [inference]

positive regulation of inhibitory postsynaptic potential

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of smooth muscle contraction [inference]

positive regulation of smooth muscle contraction [inference]

positive regulation of uterine smooth muscle contraction

regulation of uterine smooth muscle contraction [inference]

positive regulation of uterine smooth muscle contraction

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction [inference]

positive regulation of uterine smooth muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system process [inference]

positive regulation of inhibitory postsynaptic potential

positive regulation of heat generation

positive regulation of muscle contraction [inference]

positive regulation of smooth muscle contraction [inference]

positive regulation of uterine smooth muscle contraction

regulation of biological quality [inference]

regulation of blood pressure [inference]

negative regulation of blood pressure

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

regulation of membrane potential [inference]

modulation of inhibitory postsynaptic potential [inference]

positive regulation of inhibitory postsynaptic potential

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrion	ISS
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	HTP
mitochondrial matrix	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

4-aminobutyrate transaminase complex

catalytic complex [inference]

transferase complex [inference]

4-aminobutyrate transaminase complex

cellular anatomical structure [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
pyridoxal phosphate binding	IDA
pyridoxal phosphate binding	IBA
pyridoxal phosphate binding	IEA
succinate-semialdehyde dehydrogenase binding	ISS
4-aminobutyrate:2-oxoglutarate transaminase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring nitrogenous groups [inference]

transaminase activity [inference]

binding [inference]

protein binding [inference]

enzyme binding [inference]

succinate-semialdehyde dehydrogenase binding

identical protein binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

4-aminobutyrate

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
4-aminobutyrate transaminase activity
catalytic activity
gamma-aminobutyric acid catabolic process
gamma-aminobutyric acid metabolic process
pyridoxal phosphate binding
transaminase activity

Displaying **all 6** entries
InterPro
4-aminobutyrate aminotransferase, eukaryotic
Aminotransferase class-III
Aminotransferases class-III pyridoxal-phosphate attachment site
Pyridoxal phosphate-dependent transferase, major domain
Pyridoxal phosphate-dependent transferase, small domain
Pyridoxal phosphate-dependent transferase

Human Protein Atlas

ENSG00000183044

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K13524

Name

4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase [EC:2.6.1.19 2.6.1.22]

References

10989446

Rhea

RHEA:23352

2-oxoglutarate + 4-aminobutanoate

L-glutamate + succinate semialdehyde

Enzyme

2.6.1.19

PMID

RHEA:13993

2-oxoglutarate + (S)-3-amino-2-methylpropanoate

L-glutamate + 2-methyl-3-oxopropanoate

Enzyme

2.6.1.22

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060174	GABA aminotransferase deficiency	Alliance of Genome Resources
DOID:12858	Huntington's disease	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 17 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000098	Tall stature
HP:0000278	Retrognathia
HP:0000494	Downslanted palpebral fissures
HP:0001250	Seizure
HP:0001252	Hypotonia
HP:0001254	Lethargy
HP:0001263	Global developmental delay
HP:0001274	Agenesis of corpus callosum
HP:0001321	Cerebellar hypoplasia