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dipeptidyl peptidase 4

Summary

Gene Symbol

DPP4

Organism

Homo sapiens (human)

External Links

NCBI Gene

1803

KEGG Gene ID

[""]

PubChem

1803

Alliance of Genome Resources

HGNC:3009

Annotation

Keyword

3D-structure
Aminopeptidase
Cell adhesion
Cell junction
Cell membrane
Cell projection
Direct protein sequencing
Disulfide bond
Glycoprotein
Host-virus interaction
Proteomics identification
Receptor
Reference proteome
Secreted
Serine protease
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P27487	ADABP Adenosine deaminase complexing protein 2 Dipeptidyl peptidase IV T-cell activation antigen CD26 TP103
A0A7I2V2X8	Dipeptidyl peptidase IV T-cell activation antigen CD26

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
behavioral fear response
response to hypoxia	IDA
proteolysis	IDA
proteolysis	IBA
proteolysis	IEA

GO Hierarchy

biological process

immune system process [inference]

lymphocyte costimulation [inference]

T cell costimulation

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

cell adhesion

metabolic process [inference]

hormone metabolic process [inference]

peptide hormone processing

glucagon processing

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glucagon processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glucagon processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glucagon processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

glucagon processing

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

cell motility [inference]

cell migration [inference]

endothelial cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane fusion

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

behavior [inference]

behavioral defense response [inference]

behavioral fear response

locomotory behavior [inference]

locomotory exploration behavior

exploration behavior [inference]

locomotory exploration behavior

motor behavior [inference]

psychomotor behavior

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

adhesion of symbiont to host [inference]

adhesion of symbiont to host cell [inference]

virion attachment to host cell [inference]

receptor-mediated virion attachment to host cell

symbiont entry into host [inference]

symbiont entry into host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

response to stimulus [inference]

response to stress [inference]

response to hypoxia

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cell-cell adhesion mediated by integrin

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cell adhesion mediated by integrin [inference]

regulation of cell-cell adhesion mediated by integrin

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cellular component organization [inference]

negative regulation of cellular component organization [inference]

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of extracellular matrix organization [inference]

regulation of extracellular matrix disassembly [inference]

negative regulation of extracellular matrix disassembly

negative regulation of extracellular matrix organization [inference]

negative regulation of extracellular matrix disassembly

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of leukocyte chemotaxis [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of granulocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

regulation of neutrophil migration [inference]

regulation of neutrophil chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of leukocyte migration [inference]

negative regulation of leukocyte chemotaxis [inference]

negative regulation of granulocyte chemotaxis [inference]

negative regulation of neutrophil chemotaxis

negative regulation of neutrophil migration [inference]

negative regulation of neutrophil chemotaxis

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

glucagon processing

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
extracellular region	EXP
extracellular region	TAS
extracellular region	IEA
lysosomal membrane	HDA
plasma membrane	EXP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

lamellipodium membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

anchoring junction

cell-cell junction [inference]

intercellular canaliculus

cell-substrate junction [inference]

focal adhesion

leading edge membrane [inference]

lamellipodium membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
virus receptor activity	IDA
protease binding	IPI
aminopeptidase activity
serine-type endopeptidase activity	EXP
serine-type endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

exopeptidase activity [inference]

serine-type exopeptidase activity [inference]

tripeptidyl-peptidase activity

binding [inference]

protein binding

signaling receptor binding

enzyme binding [inference]

protease binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

exogenous protein binding [inference]

virus receptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

peptidase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type peptidase activity

Displaying **all 3** entries
InterPro
Alpha/Beta hydrolase fold
Dipeptidylpeptidase IV, N-terminal domain
Peptidase S9, prolyl oligopeptidase, catalytic domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0080642	Middle East respiratory syndrome	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements